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Leaflet: Operative Steps for Interventional Studies in Neuroscience.
Neurol Int
December 2024
Santa Lucia Foundation, IRCCS Fondazione Santa Lucia, 00179 Rome, Italy.
Background/objectives: Drug development involves multiple stages, spanning from initial discovery to clinical trials. This intricate process entails understanding disease mechanisms, identifying potential drug targets, and evaluating the efficacy and safety of candidate drugs. Clinical trials are designed to assess the effects of drugs on humans, focusing on determining safety profiles, appropriate modes of administration, and comparative efficacy against placebos.
View Article and Find Full Text PDFInterrupted time series datasets from studies investigating the impact of interventions or exposures in public health and social science: a data note.
BMC Res Notes
January 2025
School of Public Health and Preventive Medicine, Monash University, Level 4, 553 St Kilda Road, Melbourne, VIC, 3004, Australia.
Objectives: The interrupted time series (ITS) design is commonly used to investigate the impact of an intervention or exposure in public health. There are many statistical methods that can be used to analyse ITS data and to meta-analyse their results. We undertook two empirical studies to investigate: (i) how effect estimates (and associated statistics) compared when six statistical methods were applied to 190 real-world datasets; and (ii) how meta-analysis effect estimates (and associated statistics) compared when the combinations of two ITS analysis methods and five meta-analysis methods were applied to 17 real-world meta-analyses including 283 ITS datasets.
View Article and Find Full Text PDFOptimising data sharing whilst protecting participant privacy: a data note describing processed data from a qualitative study of healthcare professionals' experiences of caring for women with false positive screening test results.
Health Psychol Behav Med
January 2025
Manchester Centre for Health Psychology, Division of Psychology and Mental Health, School of Health Sciences, University of Manchester, Manchester, UK.
Introduction: The present article describes the processed data generated in a qualitative interview study and template analysis. Many women find the experience of being recalled and receiving a false-positive breast screening test result to be distressing. The interview study aimed to understand breast screening healthcare professionals' (HCPs) experiences of providing care during the recall process and when receiving false-positive screening test results, including their communication with women around false-positive screening test results.
View Article and Find Full Text PDFPurpose: Heart failure (HF) is a disease that leads to approximately 300,000 fatalities annually in Europe and 250,000 deaths each year in the United States. Type 2 Diabetes Mellitus (T2DM) is a significant risk factor for HF, and testing for N-terminal (NT)-pro hormone BNP (NT-proBNP) can aid in early detection of HF in T2DM patients. We therefore developed and validated the HFriskT2DM-HScore, an algorithm to predict the risk of HF in T2DM patients, so guiding NT-proBNP investigation in a primary care setting.
View Article and Find Full Text PDFMotivational influence of virtual reality in physical therapy for children with cerebral palsy: a systematic review protocol.
BMJ Open
January 2025
Physiotherapy Program, Center for Rehabilitation and Special Needs Studies, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia
Introduction: Emulating the vast inclusion of advanced technology in everyday practice, the medical world is no exception to its implementation, in particular, virtual reality (VR). Initially, its introduction as a therapy was accompanied by high aspirations and expectations for its growth and potential. Motivation is said to be the most associated benefit; although it is imperative to note that there exists a paucity of research that specifically quantifies its tangible impact on cerebral palsy (CP).
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