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| http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0140080 | PLOS |
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Assessing the Causal Relationships Between Lipid Species and Stroke by Using Mendelian Randomization.
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College of Pulmonary and Critical Care Medicine, Chinese PLA General Hospital, Beijing, 100039, China.
Circulating lipids and changes in lipid profiles have long been associated with the development of stroke but causal relationships remain unclear.In this study, we aimed to assess the causal relationships between lipid species and multiple stroke phenotypes to inform stroke prevention and treatment strategies. We conducted a two-sample Mendelian randomization analysis using data from genome-wide association studies.
View Article and Find Full Text PDFEvaluating the association between lipidome and female reproductive diseases through comprehensive Mendelian randomization analyses.
Sci Rep
January 2025
Department of Anesthesiology, The Sixth Medical Center of PLA General Hospital, Beijing, 100048, China.
This study aimed to assess the causal relationship between lipidome and female reproductive diseases (FRDs) using an advanced series of Mendelian randomization (MR) methods. This study utilized genome-wide association study (GWAS) summary statistics encompassing 179 lipidomes and six prevalent FRDs, namely polycystic ovary syndrome (PCOS), endometriosis, uterine fibroid, female infertility, uterine endometrial cancer, and ovarian cancer. The two-sample MR (TSMR) approach was employed to investigate the causal relationships, with further validation using false discovery rate (FDR) and multivariable MR (MVMR) methods.
View Article and Find Full Text PDFThe Preventive Effect of Zinc Sulfate against Olanzapine-Induced Testicular Toxicity in Male Rats.
Biol Trace Elem Res
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Institute of Specific Prophylaxis and Tropical Medicine [ISPTM], Center for Pathophysiology, Infectiology and Immunology [CePII], Ocular Immunology & Infectiology, Medical University of Vienna, Vienna, Austria.
Male infertility is a complex and multifactorial clinical condition affecting a large population attributed to several factors, including perturbation in oxidative stress and the level of essential trace elements. Oxidative stress exerts multiple issues related to reproductive health, including male infertility, decreased sperm motility, sperm DNA damage, and an increased susceptibility to genetic disorders. Besides chemical toxins and food allergens in junk food items, many drugs can also lead to male infertility.
View Article and Find Full Text PDFTargeted metabolomics identified novel metabolites, predominantly phosphatidylcholines and docosahexaenoic acid-containing lipids, predictive of incident chronic kidney disease in middle-to-elderly-aged Chinese adults.
Metabolism
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Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. Electronic address:
Background: Evidence is limited regarding the association of circulating metabolites with decline of kidney function, letting alone their value in prediction of development of chronic kidney disease (CKD).
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Long-chain polyunsaturated fatty acid-containing phosphatidylcholines predict survival rate in patients after heart failure.
Heliyon
November 2024
Department of Cardiology, University Hospital Motol and 2nd Faculty of Medicine, Charles University, Prague, Czech Republic.
Background: Heart failure (HF) is becoming an increasingly prevalent issue, particularly among the elderly population. Lipids are closely associated with cardiovascular disease (CVD) pathology. Lipidomics as a comprehensive profiling tool is showing to be promising in the prediction of events and mortality due to CVD as well as identifying novel biomarkers.
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