Previous chemical heater designs for isothermal nucleic acid amplification have been based on solid-liquid phase transition, but using this approach, developers have identified design challenges en route to developing a low-cost, disposable device. Here, we demonstrate the feasibility of a new heater configuration suitable for isothermal amplification in which one reactant of an exothermic reaction is a liquid-gas phase-change material, thereby eliminating the need for a separate phase-change compartment. This design offers potentially enhanced performance and energy density compared to other chemical and electric heaters.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4591995 | PMC |
| http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0139449 | PLOS |
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