AI Article Synopsis
- New tricyclic antitubercular ozonides, specifically compounds 9 and 10 from artemisinin, were synthesized with yields of 39% and 9%, respectively.
- The ozonide groups in compounds 9 and 10 demonstrated stability in both strong acidic and basic environments.
- Ozonide 10 exhibited significant antitubercular activity against two strains of M. tuberculosis, with minimum inhibitory concentration (MIC) values of 0.39 μg/mL for H37Ra and 3.12 μg/mL for H37Rv.
Article Abstract
New, highly stable tricyclic antitubercular ozonides 9 and 10 derived from artemisinin are reported in 39 and 9% yields, respectively. The ozonide groups of 9 and 10 were found to be stable under strong basic and acidic conditions. The absolute configuration of ozonides 9 was confirmed by X-ray crystallography. Ozonide 10 shows promising antitubercular activity against M. tuberculosis H37Ra and M. tuberculosis H37Rv with MIC values of 0.39 and 3.12 μg/mL, respectively.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acs.orglett.5b02296 | DOI Listing |
Publication Analysis
Top Keywords
stable tricyclic
8
tricyclic antitubercular
8
antitubercular ozonides
8
ozonides derived
8
derived artemisinin
8
artemisinin highly
4
highly stable
4
artemisinin reported
4
reported yields
4
yields ozonide
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!