AI Article Synopsis
- Adult-generated dentate granule neurons play a key role in the hippocampus's ability to adapt and change, known as plasticity.
- The formation of these new neurons involves neural stem cells going through various stages of growth, influenced by specific transcription factors that regulate gene expression at each stage.
- The review discusses how these transcription factor networks not only guide the proper development of neurons but also adjust the pace and timing of new neuron production based on changing conditions, offering insights into how neurogenesis impacts health and disease.
Article Abstract
Adult-generated dentate granule neurons have emerged as major contributors to hippocampal plasticity. New neurons are generated from neural stem cells through a complex sequence of proliferation, differentiation, and maturation steps. Development of the new neuron is dependent on the precise temporal activity of transcription factors, which coordinate the expression of stage-specific genetic programs. Here, we review current knowledge in transcription factor-mediated regulation of mammalian neural stem cells and neurogenesis and will discuss potential mechanisms of how transcription factor networks, on one hand, allow for precise execution of the developmental sequence and, on the other hand, allow for adaptation of the rate and timing of adult neurogenesis in response to complex stimuli. Understanding transcription factor-mediated control of neuronal development will provide new insights into the mechanisms underlying neurogenesis-dependent plasticity in health and disease.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588059 | PMC |
| http://dx.doi.org/10.1101/cshperspect.a018879 | DOI Listing |
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