Somatic structural variants in tumor genomes can deregulate transcription through repositioning of enhancer elements. A new method, PEAR-ChIP, leverages paired-end H3K27ac chromatin immunoprecipitation combined with high-throughput sequencing and current computational methods to identify such events.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608252 | PMC |
| http://dx.doi.org/10.1158/2159-8290.CD-15-0985 | DOI Listing |
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