AI Article Synopsis

  • Serum microRNAs, specifically miR-378 and miR-210, show potential as non-invasive biomarkers for early detection of renal cell carcinoma (RCC) through blood tests.
  • In a study of 195 RCC patients and 100 healthy controls, elevated levels of these microRNAs differentiated patients from controls with 80% sensitivity and 78% specificity.
  • Post-surgery evaluations revealed a significant decrease in miR-378 and miR-210 levels, with higher levels of miR-378 correlating with better disease-free survival and advanced clinical stages of RCC.

Article Abstract

Serum microRNAs are emerging as a clinically useful tool for early and non-invasive detection of various cancer types including renal cell carcinoma (RCC). Based on our previous results, we performed the study to analyze circulating serum miR-378 and miR-210 in patients with various histological subtypes of RCC. RNA was purified from blood serum samples of 195 RCC patients and 100 healthy controls. The levels of miR-378 and miR-210 in serum were determined absolutely using quantitative real-time PCR. Pre- and postoperative levels of both microRNAs were compared in 20 RCC patients. Significantly increased serum levels of both miR-378 and miR-210 enabled to clearly distinguish RCC patients and healthy controls with 80% sensitivity and 78% specificity if analyzed in combination (p<0.0001), and their levels significantly decreased in the time period of three months after radical nephrectomy (p<0.0001). Increased level of miR-378 positively correlates with disease-free survival (p=0.036) and clinical stage (p=0.0476). The analysis of serum miR-378 and miR-210 proved their potential to serve as powerful non-invasive diagnostic and prognostic biomarkers in RCC.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4632704PMC
http://dx.doi.org/10.3390/ijms161023382DOI Listing

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