AI Article Synopsis
- - The study aimed to evaluate a simple nut and bolt task to identify and measure motor impairments in premanifest and manifest Huntington's disease (HD) patients. - Participants included 24 premanifest HD patients, 27 manifest HD patients, and 32 control subjects, who were asked to complete the task using both hands with various bolt sizes. - Results showed motor impairments in all HD stages, with premanifest patients showing non-dominant hand deficits related to disease severity, suggesting this task could be a practical tool for assessing motor function in clinical settings.
Article Abstract
Background: We investigated the use of a simple novel nut and bolt task in premanifest and manifest Huntington's disease (HD) patients to detect and quantify motor impairments at all stages of the disease.
Methods: Premanifest HD (n=24), manifest HD (n=27) and control (n=32) participants were asked to screw a nut onto a bolt in one direction, using three different sized bolts with their left and right hand in turn.
Results: We identified some impairments at all stages of HD and in the premanifest individuals, deficits in the non-dominant hand correlated with disease burden scores.
Conclusion: This simple, cheap motor task was able to detect motor impairments in both premanifest and manifest HD and as such might be a useful quantifiable measure of motor function for use in clinical studies.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4570842 | PMC |
| http://dx.doi.org/10.1371/currents.hd.ded251617ae62a1364506b0521bd3761 | DOI Listing |
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