AI Article Synopsis
- Platicur, a curcumin-bound cis-diammineplatinum(II) complex, acts as a novel photoactivated chemotherapeutic agent that releases active compounds when exposed to visible light.
- Binding with platinum(II) enhances the stability of curcumin and enables interactions with DNA, leading to platinum-DNA adducts upon light exposure.
- The compound exhibits significant photocytotoxicity against cancer cells while being inactive in darkness, suggesting its potential for combined chemotherapy and phototherapy.
Article Abstract
[Pt(cur)(NH3)2](NO3) (1), a curcumin-bound cis-diammineplatinum(II) complex, nicknamed Platicur, as a novel photoactivated chemotherapeutic agent releases photoactive curcumin and an active platinum(II) species upon irradiation with visible light. The hydrolytic instability of free curcumin reduces upon binding to platinum(II). Interactions of 1 with 5'-GMP and ct-DNA indicated formation of platinum-bound DNA adducts upon exposure to visible light (λ=400-700 nm). It showed apoptotic photocytotoxicity in cancer cells (IC50 ≈ 15 μM), thus forming (⋅)OH, while remaining passive in the darkness (IC50 >200 μM). A comet assay and platinum estimation suggest Pt-DNA crosslink formation. The fluorescence microscopic images showed cytosolic localization of curcumin, thus implying possibility of dual action as a chemo- and phototherapeutic agent.
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| http://dx.doi.org/10.1002/anie.201507281 | DOI Listing |
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