We aimed to describe the in vivo activity of humanized pharmacokinetic exposures of meropenem and comparators against Verona integron-encoded metallo-β-lactamase (MBL) (VIM)-producing Enterobacteriaceae in a murine model. Levofloxacin activity was predicted by its MIC, and cefepime activity displayed variability, whereas meropenem produced a >1 log CFU reduction against all isolates despite high MICs indicative of resistance. Our results suggest that despite in vitro resistance, high-dose meropenem may be a possible option against infections caused by Enterobacteriaceae producing MBL-type carbapenemases.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4604359 | PMC |
| http://dx.doi.org/10.1128/AAC.00794-15 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Corrigendum to "Simultaneous post-neurosurgical ventriculitis and bacteraemia by two different strains of KPC-producing K. pneumoniae successfully treated with meropenem/vaborbactam and high dose of Fosfomycin" [Journal of Global Antimicrobial Resistance 37 (2024) 86-90].
J Glob Antimicrob Resist
January 2025
Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy. Electronic address:
Effect of Meropenem on Conjugative Plasmid Transfer in .
Int J Mol Sci
December 2024
Department of Pharmacokinetics & Pharmacodynamics, Gause Institute of New Antibiotics, 11 Bolshaya Pirogovskaya Street, 119021 Moscow, Russia.
Plasmid-mediated resistance is a major mechanism that contributes to the gradual decline in the effectiveness of antibiotics from different classes, including carbapenems. Antibiotics can significantly contribute to the efficiency of plasmid transfer between bacterial strains. To investigate the potential effect of an antibiotic on the efficacy of conjugative plasmid transfer, we conducted mating experiments with strains.
View Article and Find Full Text PDFPK/PD modelling and simulation of longitudinal meropenem in vivo effects against Escherichia coli and Klebsiella pneumoniae strains with high MICs.
Int J Antimicrob Agents
December 2024
Department of Pharmacy, Uppsala University, Uppsala, Sweden. Electronic address:
Background: Carbapenem-resistant bacteria pose a threat to public health. Characterising the pharmacokinetics-pharmacodynamics (PKPD) of meropenem longitudinally in vivo against resistant bacteria could provide valuable information for development and translation of carbapenem-based therapies.
Objectives: To assess the time course of meropenem effects in vivo against strains with high MIC to predict PK/PD indices and expected efficacy in patients using a modelling approach.
Outcome of carbapenem or colistin resistant Klebsiella pneumoniae bacteremia in the intensive care unit.
Sci Rep
October 2024
Faculty of Medicine, Dept. of Anesthesiology and Reanimation ICU, Bursa Uludağ Univ, Görükle Campus - Nilüfer, 16059, Bursa, Türkiye.
Carbapenem-resistant Klebsiella pneumoniae (CRKp) infections continue to be an important cause of mortality. In this retrospective study, the effect of carbapenem or colistin resistance on mortality in Klebsiella pneumoniae bacteremia and combined meropenem + colistin administration in CRKp bacteremia was evaluated. In addition to that, a mathematical model is applied to explore the relationships between the resistance and mortality.
View Article and Find Full Text PDFIs the high dose extended infusion of meropenem useful in the treatment of highly resistant gram-negative bacteria in children?
J Infect Chemother
August 2024
Hacettepe University Faculty of Medicine, Department of Pediatric Infectious Diseases, Ankara, Turkey. Electronic address:
Objectives: Multidrug resistant infections present a treatment challenge for clinicians. These infections have been associated with increased morbidity and mortality. Recently, there has been increasing discussion in the literature that high dose extended infusion of meropenem may be helpful.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!