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Factors affecting posaconazole plasma concentrations: a meta-analysis and systematic review.
Front Pharmacol
December 2024
Department of Clinical Pharmacy, The First Hospital of Hebei Medical University, Shijiazhuang, China.
Background: Posaconazole is a potent antifungal agent widely used to manage invasive fungal infections, especially in immunocompromised individuals. Achieving optimal therapeutic concentrations of posaconazole can be challenging due to interpatient variability, the availability of multiple formulations, and various dosing strategies.
Methods: We conducted a systematic search of PubMed, EMBASE, and the Cochrane Library to identify studies evaluating factors that influence blood concentrations of posaconazole.
Diffusion of fast and slow excitons with an exchange in quasi-two-dimensional systems.
Phys Rev E
November 2024
Skolkovo Institute of Science and Technology, Bolshoy Boulevard 30, Moscow 121205, Russia.
By means of analytical calculations and numerical simulations, we study the diffusion properties in quasi-two-dimensional structures with two exciton subsystems with an exchange between them. The experimental realization is possible in systems where fast and slow exciton subsystems appear. For substantially different diffusion coefficients of the species, the negative diffusion can be observed if one measures the transport properties of only a single subsystem, just as was obtained in experimental studies for quasi-two-dimensional semiconductor systems.
View Article and Find Full Text PDFExperimental Measurements of the Length of the Human Colon: A Systematic Review and Meta-Analysis.
Diagnostics (Basel)
September 2024
Translational Medical Sciences, Nottingham Digestive Diseases Centre, School of Medicine, University of Nottingham, Nottingham NG7 2UH, UK.
Purpose: Knowledge of the length of the colon is relevant to understanding physiological and pathological function. It also has implications for diagnostic and clinical interventions, as well as for the design of delayed-release drug formulations and drug disposition modeling.
Methods: Over the years, a range of different experimental methods have been employed to assess colon length.
Survival of Probiotic Bacterial Cells in the Upper Gastrointestinal Tract and the Effect of the Surviving Population on the Colonic Microbial Community Activity and Composition.
Nutrients
August 2024
Heights, Department for Research and Development, London W1D 2LG, UK.
Many health-promoting effects have been attributed to the intake of probiotic cells. However, it is important that probiotic cells arrive at the site of their activity in a viable state in order to exert their beneficial effects. Careful selection of the appropriate probiotic formulation is therefore required as mainly the type of probiotic species/strain and the administration strategy may affect survival of the probiotic cells during the upper gastrointestinal (GIT) passage.
View Article and Find Full Text PDFMelatonin Bioavailability After Oral Administration of a New Delayed-Release Form in Healthy Male Volunteers.
Drugs R D
September 2024
, 127 chemin de Bois Vieux, 26400, Aouste-sur-Sye, France.
Background: Two main types of galenic formulation, immediate release and prolonged release, have been developed to optimize melatonin bioavailability. We recently described the kinetic profile of a prolonged-release form generating a peak of plasma melatonin 1 h (T) after intake, followed by a prolonged decay over time. We have developed a new oral form of melatonin with the aim of producing a melatonin peak several hours after intake.
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