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Interference by vitamin B12-macrocomplexes: towards an effective detection and correct interpretation of hypo- and hypervitaminemia.
Adv Lab Med
December 2024
Department of Laboratory Medicine, Hospital Universitari Son Espases, Palma, Spain.
Objectives: The presence of macro-B12 is a cause of factual hypervitaminemia B12. Precipitation with polyethylene glycol (PEG) is a simple method of removing high-molecular-weight biomolecules. However, "free" molecule may co-precipitate.
View Article and Find Full Text PDFChallenges in the diagnosis of hypervitaminemia B12. Interference by immunocomplexes.
Clin Chim Acta
February 2023
Department of Laboratory Medicine, Hospital Universitari Son Espases, Palma, Spain; Institut d́Investigació Sanitària de les Illes Balears (IdISBa), Spain.
Background-aim: High vitamin B12 concentrations are considered a common finding in clinical practice. Thanks to immunoassay accessibility, vitamin B12 has become a usual test in routine health checkups. However, these analytical methods usually present antibody-mediated interferences.
View Article and Find Full Text PDFPersistently increased vitamin B12 concentration due to cobalamin macrocomplexes: a case report and review of the literature.
Clin Chem Lab Med
September 2020
Department of Laboratory Medicine, Hospital Universitari Son Espases, Ctra. de Valldemossa, Mallorca, Spain.
[Hypervitaminosis B12. Our experience and a review].
Medicina (B Aires)
December 2019
Service de Médecine Interne, Diabète et Maladies Métaboliques, Hôpitaux Universitaires de Strasbourg, France. E-mail:
High serum levels of vitamin B12 or cobalamin, also called hypervitaminemia B12, is a frequently underestimated biological abnormality. According to the literature, some of the entities related to this finding are solid neoplasia (primary or metastatic) and acute or chronic hematological diseases. Other causes include liver disorders, monoclonal gammapathy of undetermined significance, renal failure and, less frequently, excess of vitamin B12 intake, inflammatory or autoimmune diseases, and transient hematological disorders (neutrophilia and secondary eosinophilia).
View Article and Find Full Text PDF[What to do before a hypervitaminia B12 in the elderly].
Soins Gerontol
August 2017
Département de médecine interne, CHRU Strasbourg, 67000 Strasbourg, France.
Hypervitanimia B12 is an early marker of serious pathologies. These include solid neoplasms, malignant blood diseases and acute/chronic hepatopathies. Hypervitaminemia B12 in geriatrics is thereby an indicator in the diagnosis and prognosis of these conditions.
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