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Quantitative Structure-Cytotoxicity Relationship of 3-Styryl-2H-chromenes. | LitMetric

AI Article Synopsis

  • The study analyzed sixteen 3-styryl-2H-chromene compounds for their potential cytotoxicity, tumor selectivity, and anti-HIV activity, aiming to identify new biological applications.
  • Researchers used various methods to assess cytotoxicity against cancer and normal oral cell lines, evaluated tumor selectivity through CC50 ratios, and found no anti-HIV activity in any compounds tested.
  • One specific compound demonstrated superior tumor selectivity and potency compared to well-known drugs like resveratrol and doxorubicin, suggesting that molecular shape and flatness could be key aspects in evaluating tumor-specificity.

Article Abstract

Background: Sixteen 3-styryl-2H-chromenes were subjected to quantitative structure-activity relationship analysis based on their cytotoxicity, tumor selectivity and anti-HIV activity, in order to find their new biological activities.

Materials And Methods: Cytotoxicity against four human oral squamous cell carcinoma (OSCC) cell lines, three mesenchymal and two epithelial normal oral cells was determined by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide method. Tumor-selectivity (TS) was evaluated by the ratio of the mean CC50 (50% cytotoxic concentration) against normal human oral cells to that against OSCC cell lines. Anti-HIV activity was evaluated by the ratio of CC50 to EC50 (50% cytoprotective concentration from HIV infection). Potency-selectivity expression (PSE) was determined by the ratio of TS/CC50 against OSCC. Physicochemical, structural and quantum-chemical parameters were calculated based on the conformations optimized by the LowModeMD method.

Results: All 3-styryl-2H-chromene derivatives showed relatively high tumor selectivity. Especially, the compound that has a methoxy group at 7-position of the chromene ring and chlorine at 4'-position of phenyl group in styryl moiety [ 12: ] showed the highest TS and PSE values, exceeding those of resveratrol, doxorubicin and 5-FU. All compounds showed no anti-HIV activity. Among 330 chemical descriptors, 8, 74 and 16 descriptors significantly correlated to the cytotoxicity of normal and tumor cells, and tumor-specificity, respectively.

Conclusion: Multivariate statistics with chemical descriptors for molecular shape and flatness may be useful for the evaluation of tumor-specificity of 3-styryl-2H-chromenes.

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