Aim: Normocholesterolemic subjects with elevated fasting plasma triglycerides are at increased risk of atherosclerosis through mechanisms that are not yet delineated. We hypothesized that elevated plasma triglyceride is associated with increased vascular exposure to pro-atherogenic lipoprotein remnants. To test this hypothesis, the abundance, and size distribution of chylomicron particles were determined in individuals with and without hypertriglyceridemia.
Methods: Twelve hypertriglyceridemic subjects (HTG group, triglyceride concentration ≥1.7 mmol/L) and twelve normotriglyceridemic subjects (NTG group) matched for age and gender were studied. The distribution of chylomicron particles was assessed by determining the fasting concentration of apo B-48 in serum lipoprotein fractions with Svedberg flotation rates of (Sf) > 400, Sf 20-400 and Sf < 20.
Results: The total concentration of apo B-48 in subjects with HTG was almost twice that observed in NTG controls with ∼80% of the increase residing in the Sf < 20 fraction (HTG: 8.7 ± 1.0 μg/mL vs NTG: 5.0 ± 0.6 μg/mL; P = 0.016). Significantly greater concentrations of apo B-48 were also observed in the less dense Sf 20-400 (HTG: 1.1 ± 0.2 μg/mL vs NTG: 0.4 ± 0.07 μg/mL; P < 0.001) and the Sf > 400 (HTG: 1.1 ± 0.3 μg/mL vs NTG: 0.3 ± 0.04 μg/mL; P < 0.001) fractions. An accumulation of triglyceride was also observed across all lipoprotein fractions in HTG subjects compared to NTG (Sf 400 & Sf 20-400: P < 0.001 and Sf < 20: P = 0.013).
Conclusion: Normocholesterolemic, moderately hypertriglyceridemic subjects are at increased atherogenic risk due to greater apo B-48 concentration in the small, dense lipoprotein fraction.
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http://dx.doi.org/10.1016/j.atherosclerosis.2015.09.018 | DOI Listing |
Biochim Biophys Acta Mol Cell Biol Lipids
November 2024
Department of Pediatrics and Group on the Molecular and Cell Biology of Lipids, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada. Electronic address:
Surfeit locus protein 4 (SURF4) acts as a cargo receptor to mediate endoplasmic reticulum export of various cargos. We have shown that SURF4 is essential for secretion of hepatic very low-density lipoprotein and intestinal chylomicron. Knockdown of hepatic Surf4 also significantly reduces the development of atherosclerosis and liver fibrosis without causing overt liver damage.
View Article and Find Full Text PDFClin Kidney J
October 2024
Division of Clinical Chemistry, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.
Introduction: Transplant vasculopathy resembles atherosclerotic plaque formation and is a major contributor to late graft failure in kidney transplant recipients (KTR). Remnant lipoproteins and associated triglycerides are causal risk factors for atherosclerotic plaques and have been implicated in late kidney graft failure. However, whether remnants derived from liver (containing apolipoprotein [apo] B100) or intestine (containing apoB48) are clinically more important is unclear.
View Article and Find Full Text PDFJ Atheroscler Thromb
July 2024
Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine.
J Atheroscler Thromb
November 2024
Center for Preventive, Anti-aging and Regenerative Medicine, Fukuoka University Hospital.
Abetalipoproteinemia (ABL) is a rare disease characterized by extremely low apolipoprotein B (apoB)-containing lipoprotein levels, dietary fat, and fat-soluble vitamin malabsorption, leading to gastrointestinal, neuromuscular, and ophthalmological symptoms. We herein report a case of ABL with novel compound heterozygous mutations in the microsomal triglyceride transfer protein gene (c.1686_1687del [p.
View Article and Find Full Text PDFCardiovasc Res
May 2024
Cardiovascular Program-ICCC, Institut d'Investigació Biomèdica Sant Pau (IIB SANT PAU), Sant Antoni Mª Claret 167, Barcelona 08025, Spain.
Aims: Probiotics with high bile salt hydrolase (BSH) activity have shown to promote cardiovascular health. However, their mechanism(s) of action remain poorly understood. Here, we performed a pilot exploratory study to investigate effects of a 4-week intervention with escalating doses of a BSH-active formula containing Lactiplantibacillus plantarum strains KABP011, KABP012, and KABP013 on bile acid (BA), lipid profile, and lipoprotein function.
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