Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.ygyno.2015.09.017 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
[Analysis of Genes Related to Platelet Activation in Essential Thrombocythemia Based on Transcriptomics].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
December 2024
Department of Hematology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China.
Objective: To analyze the genes related to platelet activation in essential thrombocythemia (ET) based on transcriptome sequencing technology (RNA-seq), and to explore the potential targets related to ET thrombosis.
Methods: Blood samples from ET patients and healthy individuals were collected for RNA-seq, and differentially expressed lncRNAs, miRNAs, and mRNAs were selected to construct a lncRNA-miRNA-mRNA regulatory network. Differential mRNAs in the regulatory network were enriched and analyzed using Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG).
Development and validation of a deep learning model for morphological assessment of myeloproliferative neoplasms using clinical data and digital pathology.
Br J Haematol
December 2024
Department of Haematology, Collaborative Innovation Center for Cancer Personalized Medicine, Jiangsu Province Hospital, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
The subjectivity of morphological assessment and the overlapping pathological features of different subtypes of myeloproliferative neoplasms (MPNs) make accurate diagnosis challenging. To improve the pathological assessment of MPNs, we developed a diagnosis model (fusion model) based on the combination of bone marrow whole-slide images (deep learning [DL] model) and clinical parameters (clinical model). Thousand and fifty-one MPN and non-MPN patients were divided into the training, internal testing and one internal and two external validation cohorts (the combined validation cohort).
View Article and Find Full Text PDFMyeloproliferative Neoplasms: Challenging Dogma.
J Clin Med
November 2024
Hematology Division, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Myeloproliferative neoplasms, polycythemia vera, essential thrombocytosis, and primary myelofibrosis are a unique group of clonal hematopoietic stem cell neoplasms that share somatic, gain-in-function driver mutations in 2, , and . As a consequence, these disorders exhibit similar phenotypic features, the most common of which are the ceaseless production of normal erythrocytes, myeloid cells, platelets alone or in combination, extramedullary hematopoiesis, myelofibrosis, and a potential for leukemic transformation. In the case of polycythemia vera and essential thrombocytosis, however, prolonged survival is possible.
View Article and Find Full Text PDFRevisiting the association between pretreatment thrombocytosis and cancer survival outcomes: an umbrella review of meta-analyses.
BMC Cancer
October 2024
Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, China.
Article Synopsis
- The study conducted an umbrella review to evaluate the reliability of the link between pre-treatment thrombocytosis (high platelet count) and cancer survival outcomes, amidst debates over existing evidence.
- It analyzed 21 unique meta-analyses across ten cancer types, finding that most showed a significant association between thrombocytosis and poorer survival rates in cancer patients.
- Although the evidence was mostly classified as highly suggestive for certain cancer types, no meta-analysis achieved a high quality rating, indicating more research is needed for stronger conclusions.
Relation of V617F allele burden and coronary calcium score in patients with essential thrombocythemia.
Radiol Oncol
December 2024
Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
Article Synopsis
- The V617F mutation is linked to clonal hemopoiesis and faster progression of cardiovascular diseases, but its relationship with coronary artery atherosclerosis is not well understood.
- A study followed 36 patients with essential thrombocythemia (ET) and 38 healthy controls over four years to assess mutation burden and coronary calcium levels.
- While the overall mutation burden decreased, an increase in mutation burden correlated with a rise in coronary calcium scores, suggesting the mutation may contribute to atherosclerosis as a non-classical cardiovascular risk factor.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!