AI Article Synopsis
- Autophagy is a natural process that breaks down cellular components in lysosomes for recycling, and it's being explored as a treatment strategy alongside radiotherapy for breast cancer.
- Research shows that both autophagy and apoptosis (cell death) can be triggered by radiation, and preventing autophagy may lead to increased apoptosis in cancer cells.
- The molecule Akt suppresses autophagy and apoptosis, and inhibiting Akt could boost the effectiveness of radiation treatment in breast cancer cells, suggesting it may be a promising target in therapy.
Article Abstract
Autophagy is an evolutionarily conservation process whereby cytoplasm and cellular organelles are degraded in lysosomes for amino acid and energy recycling. Autophagy concurrent with radiotherapy has emerged as a novel approach in breast cancer treatment. Our studies conclude that autophagy and apoptosis can be induced by radiation and inhibition of autophagy can increase apoptosis. In addition, Akt is a molecule that down-regulates autophagy and apoptosis; blocking Akt can enhance autophagy and apoptosis induced by radiation in MCF-7 cells. Akt could become a new focus in breast cancer radiotherapy.
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| http://dx.doi.org/10.3233/BME-151532 | DOI Listing |
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