The question of which dendritic cells (DCs) cross-present peripheral tumor antigens remains unanswered. We assessed the ability of multiple skin-derived and lymphoid resident DCs to perform this function in a novel orthotopic murine melanoma model where tumor establishment and expansion is within the skin. Two migratory populations defined as CD103XCR1 and CD103XCR1 efficiently cross-presented melanoma-derived antigen, with the CD103XCR1 DCs surprisingly dominating this process. These results are critical for understanding how antitumor CD8 T cell immunity is coordinated to tumor antigens present within the skin.
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| http://dx.doi.org/10.1080/2162402X.2015.1019198 | DOI Listing |
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