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Differential gene expression in Chorthippus parallelus (Zetterstedt, 1821) (Orthoptera: Acrididae: Gomphocerinae) induced by Wolbachia infection.
Insect Sci
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Grupo de Entomología Molecular, Biomarcadores y Estrés Ambiental, Facultad de Ciencias, Universidad Nacional de Educación a Distancia (UNED), Madrid, Spain.
Distinct lineages of the grasshopper Chorthippus parallelus (Orthoptera: Acrididae) form well-known hybrid zones (HZs) both in the Pyrenees and the Alps mountain ranges in South Europe. These HZs represent unique experimental systems to identify "key genes" that maintain genetic boundaries between emerging species. The Iberian endemism C.
View Article and Find Full Text PDFTransfer of mitochondrial DNA into the nuclear genome during induced DNA breaks.
Nat Commun
November 2024
State Key Laboratory of Protein and Plant Gene Research, Genome Editing Research Center, School of Life Sciences, PKU-THU Center for Life Sciences, Peking University, Beijing, China.
Mitochondria serve as the cellular powerhouse, and their distinct DNA makes them a prospective target for gene editing to treat genetic disorders. However, the impact of genome editing on mitochondrial DNA (mtDNA) stability remains a mystery. Our study reveals previously unknown risks of genome editing that both nuclear and mitochondrial editing cause discernible transfer of mitochondrial DNA segments into the nuclear genome in various cell types including human cell lines, primary T cells, and mouse embryos.
View Article and Find Full Text PDFGenomic and transcriptomic perspectives on the origin and evolution of NUMTs in Orthoptera.
Mol Phylogenet Evol
December 2024
College of Life Sciences, Shaanxi Normal University, Xi'an, China. Electronic address:
Article Synopsis
- NUMTs (nuclear mitochondrial pseudogenes) are segments of mitochondrial DNA that have integrated into the nuclear genome, providing a unique window into evolutionary patterns.
- The study examined NUMTs in ten Orthoptera species, revealing divergence rates between NUMTs and current mitochondrial DNA ranging from 0% to 23.78%, with a significant link between NUMT insertions and transposable elements.
- A proposed mechanism for NUMT integration involves the reverse transcription of mitochondrial RNA into DNA, which occurs at low probabilities, while phylogenetic analysis of NUMTs and current mtDNA offers insights into historical evolutionary processes and species relationships.
Microcystin-LR in drinking water: An emerging role of mitochondrial-induced epigenetic modifications and possible mitigation strategies.
Toxicol Rep
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Division of Environmental Biotechnology, Genetics & Molecular Biology (EBGMB), ICMR-National Institute for Research in Environmental Health (NIREH), Bhopal, India.
Algal blooms are a serious menace to freshwater bodies all over the world. These blooms typically comprise cyanobacterial outgrowths that produce a heptapeptide toxin, Microcystin-LR (MC-LR). Chronic MC-LR exposure impairs mitochondrial-nuclear crosstalk, ROS generation, activation of DNA damage repair pathways, apoptosis, and calcium homeostasis by interfering with PC/MAPK/RTK/PI3K signaling.
View Article and Find Full Text PDFClinico-Radiological and Genotypic Spectrum of Nuclear Mitochondriopathies.
Indian J Pediatr
October 2024
Division of Genetics, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India.
Mitochondrial disorders are a diverse group of diseases caused by mutations in genes encoded by either nuclear or mitochondrial DNA. In a group of patients with nuclear mitochondriopathies, the authors analysed the clinico-radiological and genotypic spectrum. The study included 25 patients with a genetic diagnosis of nuclear mitochondrial cytopathy who were seen over a 5 y period.
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