Objective: Craving has been defined as intense desires or urges to consume alcohol and is considered predictive of future drinking and relapse. Despite this assumption, research on the craving-drinking relationship has been mixed, calling into question how researchers define and measure craving. The primary aim of the current study was to examine a promising, but understudied, model of craving (Ambivalence Model of Craving [AMC]) that calls for the concurrent assessment of both approach (desires to use) and avoidance (desires to not use) inclinations.
Method: Participants (N = 175) were recruited from an acute detoxification facility. Alcohol craving was evaluated with a cue-reactivity paradigm in which participants viewed substance cue slides and separately rated their desire to consume and not consume the substance after each image. Latent profile analysis examined distinct motivational profiles for alcohol predicted by the AMC: ambivalence (high approach, high avoidance), indifference (low approach, low avoidance), approach (high approach, low avoidance), and avoidance (low approach, high avoidance).
Results: Latent classes corresponded to the AMC, but a fifth class differentiated moderate versus high ambivalence. Classes were associated with auxiliary variables in predicted directions; high ambivalence and approach classes were associated with greater drinking and negative consequences, whereas voluntary admittance to treatment was more likely with ambivalence and avoidance classes.
Conclusions: The AMC provides a promising framework for evaluating cue-elicited craving and alcohol use in clinical samples and may be a useful model of craving for clinicians during treatment.
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http://dx.doi.org/10.15288/jsad.2015.76.764 | DOI Listing |
Psychopharmacology (Berl)
December 2024
Department of Basic Medical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, IN, 47904, USA.
Rationale: The rise in overdose deaths from synthetic opioids, especially fentanyl, necessitates the development of preclinical models to study fentanyl use disorder (FUD). While there has been progress with rodent models, additional translationally relevant models are needed to examine excessive fentanyl intake and withdrawal signs.
Objective: The current study aimed to develop a translationally relevant preclinical mouse model of FUD by employing chronic intravenous fentanyl self-administration (IVSA).
Cureus
November 2024
School of Public Health, Loma Linda University, Loma Linda, USA.
Introduction: Variation in common taste receptor type 2 member 38 (TAS2R38) haplotypes is associated with bitter taste sensitivity, but there is not much or inconsistent evidence on association with food cravings and with chronic disease risk factors. We have conducted a cross-sectional study to assess whether genetically defined taster groups would differ in their sensitivity to bitter-tasting compounds, cravings for various food groups, and risk of chronic disease risk factors. Methodology: A total of 116 non-diabetic individuals were recruited from the Loma Linda University (LLU) campus.
View Article and Find Full Text PDFBehav Pharmacol
December 2024
Department of Neural and Behavioral Sciences.
Opioid use disorder (OUD) is a crisis in the USA. Despite advances with medications for OUD, overdose deaths have continued to rise and are largely driven by fentanyl. We have previously found that male rats readily self-administer fentanyl, with evident individual differences in fentanyl taking, seeking, and reinstatement behaviors.
View Article and Find Full Text PDFInt J Neuropsychopharmacol
December 2024
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.
Background: Understanding drug addiction as a disorder of maladaptive learning, where drug-associated or environmental cues trigger drug cravings and seeking, is crucial for developing effective treatments. Actin polymerization, a biochemical process, plays a crucial role in drug-related memory formation, particularly evident in conditioned place preference (CPP) paradigms involving drugs like morphine and methamphetamine. However, the role of actin polymerization in the reconsolidation of heroin-associated memories remains understudied.
View Article and Find Full Text PDFJ Psychiatr Res
December 2024
University of Minnesota, Division of Epidemiology and Community Health, USA.
Objective: Understanding the association between cannabis use and binge eating is of interest amidst growing global cannabis legalization. While preliminary research suggests a link between cannabis use and binge eating, population-based data among young adults, both female and male, are lacking. Given that depressive symptoms can act as an important precipitant of both cannabis use and binge eating, exploring the role of depressive symptoms is essential.
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