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Predictive modelling of linear growth faltering among pediatric patients with Diarrhea in Rural Western Kenya: an explainable machine learning approach.
BMC Med Inform Decis Mak
December 2024
Kenya Medical Research Institute- Center for Global Health Research (KEMRI-CGHR), P.O Box 1578-40100, Kisumu, Kenya.
Article Synopsis
- * A machine learning approach was applied using data from the VIDA and EFGH-Shigella studies in rural Kenya to create predictive models for LGF among children aged 6-35 months, encompassing 65 potential predictors including demographic and health-related factors.
- * The models showed a prevalence of LGF at 16.9% and 22.4% in different cohorts, with the gradient boosting model providing the best prediction accuracy, demonstrating its usefulness in identifying at-risk children for targeted healthcare interventions
Whole genome sequencing and antimicrobial resistance among clinical isolates of Shigella sonnei in Addis Ababa, Ethiopia.
PLoS One
November 2024
School of Medical Laboratory Sciences, Institution of Health Sciences, Jimma University, Jimma, Ethiopia.
Article Synopsis
- Shigellosis is a major health issue in Ethiopia, particularly affecting young children, and is exacerbated by antimicrobial resistance due to misuse of antibiotics and poor hygiene.
- The study utilized whole genome sequencing (WGS) to examine Shigella sonnei strains in Addis Ababa, focusing on antibiotic resistance genes and plasmid types associated with these strains.
- Findings showed a variety of resistance genes and phenotypic resistance patterns, indicating significant genetic diversity in S. sonnei strains, which suggests the need for enhanced monitoring of antimicrobial resistance through WGS.
Alterations in the Gut Microbiota Composition in Obesity with and without Type 2 Diabetes: A Pilot Study.
Diabetes Metab Syndr Obes
October 2024
Department of Endocrinology, Beijing Tsinghua Changgung Hospital, Tsinghua University, Beijing, People's Republic of China.
Purpose: Obesity has become a major public health concern worldwide, increasing the risk of T2DM. Growing evidence indicates gut microbiota dysbiosis is related to metabolic disorders. We aimed to firstly investigate the compositional and functional features of the gut microbiome between obesity with and without T2DM in the Chinese population.
View Article and Find Full Text PDFMolecular identification and antimicrobial resistance patterns of enterobacterales in community urinary tract infections among indigenous women in Ecuador: addressing microbiological misidentification.
BMC Infect Dis
October 2024
Grupo de Investigación en Biodiversidad, Ingeniería en Biotecnología, Medio Ambiente y Salud (BIOMAS), Universidad de Las Américas 170125, Quito, Ecuador.
Background: Antibiotic resistance of Enterobacterales poses a major challenge in the treatment of urinary tract infections (UTIs). In low- and middle-income countries (LMICs), standard microbiological (i.e.
View Article and Find Full Text PDFAn RPA-Based CRISPR/Cas12a Assay in Combination with a Lateral Flow Assay for the Rapid Detection of in Food Samples.
Foods
October 2024
Institute of Food Safety and Nutrition, Jinan University, Guangzhou 510632, China.
Among the pathogens that cause infectious diarrhea in China, is the most prominent. Shigellosis affects both adults and children, particularly those in developing nations, with nearly 190 million annual cases and a third resulting in fatalities. The recently emerged CRISPR/Cas system has also been increasingly applied for the detection of different biological targets.
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