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BDNF augmentation reverses cranial radiation therapy-induced cognitive decline and neurodegenerative consequences.
Acta Neuropathol Commun
December 2024
Department of Anatomy and Neurobiology, School of Medicine, University of California, Irvine, USA.
Cranial radiation therapy (RT) for brain cancers is often associated with the development of radiation-induced cognitive dysfunction (RICD). RICD significantly impacts the quality of life for cancer survivors, highlighting an unmet medical need. Previous human studies revealed a marked reduction in plasma brain-derived neurotrophic factor (BDNF) post-chronic chemotherapy, linking this decline to a substantial cognitive dysfunction among cancer survivors.
View Article and Find Full Text PDFOligodendrocyte Progenitor Cell Transplantation Reduces White Matter Injury in a Fetal Goat Model.
CNS Neurosci Ther
December 2024
Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, NHC Key Laboratory of Chronobiology, Sichuan University, Chengdu, China.
Background: Preterm white matter injury (PWMI) is the most common type of brain injury in preterm infants, in which, oligodendrocyte progenitor cells (OPCs) are predominantly damaged. In this study, human OPCs (hOPCs) were administered to a fetal goat model of PWMI to examine the differentiation potential and therapeutic effects of the cells on PWMI.
Methods: Preterm goat fetuses were subjected to hypoxic-ischemia (HI) via intermittent umbilical cord occlusion (5 min × 5).
Expression of Neurotrophins and Its Receptors During Fetal Development in the Human Cochlea.
Int J Mol Sci
December 2024
Department of Otorhinolaryngology, Medical University Innsbruck, 6020 Innsbruck, Austria.
We determined the relative expression levels of the receptors , , , and and ligands , , , and with RNAseq analysis on fetal human inner ear samples, located TrkB and TrkC proteins, and quantified with in situ hybridization on histological sections between gestational weeks (GW) 9 to 19. Spiral ganglion neurons (SGNs) and satellite glia appear to be the main source of and synthesis peaks twice at GW10 and GW15-GW17. Tonotopical gradients of revert between GW8 and GW15 and follow a maturation and innervation density gradient in SGNs.
View Article and Find Full Text PDFThe rising incidence rate of depression presents a substantial threat to human well-being. (ST), the dried mature seeds of L., has a long-standing traditional reputation for alleviating anxiety and hopelessness.
View Article and Find Full Text PDFArticle Synopsis
- BDNF (Brain-derived neurotrophic factor) is vital for nerve cell growth and survival, with forms that bind to different receptors affecting brain development, especially during the neonatal period.
- Disruptions in BDNF levels during this critical time can lead to long-term behavioral issues, including increased anxiety and depression in adolescents.
- The study found that elevated levels of mature BDNF contributed to these behaviors, while mutant BDNF led to opposite transcriptional changes, suggesting a significant link between BDNF variations and the development of neurobehavioral disorders.
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