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Sr and Mg Doped Bi-Phasic Calcium Phosphate Macroporous Bone Graft Substitutes Fabricated by Robocasting: A Structural and Cytocompatibility Assessment.
J Funct Biomater
August 2022
National Institute of Materials Physics, RO-077125 Magurele, Romania.
Article Synopsis
- Bi-phasic calcium phosphates (BCPs) are being researched as materials for bone graft substitutes, and cation-doping might enhance their effectiveness.
- This study fabricated pure and magnesium (Mg) and strontium (Sr) doped BCP scaffolds using advanced techniques, and the results showed that all scaffold types performed similarly in promoting osteoblast cell growth, especially the ones doped with both Mg and Sr.
- The findings revealed that the double doping of Mg and Sr increased the tricalcium phosphate/hydroxyapatite ratio, which may lead to a more effective release of therapeutic ions and better performance for future medical devices.
Fish Bone Derived Bi-Phasic Calcium Phosphate Coatings Fabricated by Pulsed Laser Deposition for Biomedical Applications.
Mar Drugs
December 2020
National Institute for Lasers, Plasma and Radiation Physics, RO-077125 Magurele, Romania.
We report on new biomaterials with promising bone and cartilage regeneration potential, from sustainable, cheap resources of fish origin. Thin films were fabricated from fish bone-derived bi-phasic calcium phosphate targets pulsed laser deposition with a KrF * excimer laser source (λ = 248 nm, τ ≤ 25 ns). Targets and deposited nanostructures were characterized by SEM and XRD, as well as by Energy Dispersive X-ray (EDX) and FTIR spectroscopy.
View Article and Find Full Text PDFDirectly imaging the localisation and photosensitization properties of the pan-mTOR inhibitor, AZD2014, in living cancer cells.
J Photochem Photobiol B
December 2020
Central Laser Facility, Science & Technology Facilities Council, Rutherford Appleton Laboratory, Harwell Campus, Didcot, Oxfordshire OX11 0QX, UK. Electronic address:
The range of cellular functions the mechanistic target of rapamycin (mTOR) protein performs makes it an attractive drug target for cancer therapy. However, the cellular localisation and mode of action of second generation inhibitors of mTOR is poorly understood despite the level of attention there is in targeting the mTOR protein. We have therefore studied the properties of the pan-mTOR inhibitor AZD2014, an ideal candidate to study because it is naturally fluorescent, characterising its photochemical properties in solution phase (DMSO, PBS and BSA) and within living cells, where it localises within both the nucleus and the cytoplasm but with different excited state lifetimes of 4.
View Article and Find Full Text PDFPrototype Orthopedic Bone Plates 3D Printed by Laser Melting Deposition.
Materials (Basel)
March 2019
Center for Advanced Laser Technologies-CETAL, National Institute for Lasers, Plasma and Radiation Physics, 077125 Magurele, Ilfov, Romania.
Laser melting deposition is a 3D printing method usually studied for the manufacturing of machine parts in the industry. However, for the medical sector, although feasible, applications and actual products taking advantage of this technique are only scarcely reported. Therefore, in this study, Ti6Al4V orthopedic implants in the form of plates were 3D printed by laser melting deposition.
View Article and Find Full Text PDFNaturally-Derived Biphasic Calcium Phosphates through Increased Phosphorus-Based Reagent Amounts for Biomedical Applications.
Materials (Basel)
January 2019
Department of Metallic Materials Science, Physical Metallurgy, University Politehnica of Bucharest, 313 Splaiul Independentei, J Building, District 6, 060042 Bucharest, Romania.
Calcium carbonate from marble and seashells is an eco-friendly, sustainable, and largely available bioresource for producing natural bone-like calcium phosphates (CaPs). Based on three main objectives, this research targeted the: (i) adaptation of an indirect synthesis route by modulating the amount of phosphorus used in the chemical reaction, (ii) comprehensive structural, morphological, and surface characterization, and (iii) biocompatibility assessment of the synthesized powdered samples. The morphological characterization was performed on digitally processed scanning electron microscopy (SEM) images.
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