In rehabilitation, nurses are the first team members to note or be told when a patient is having a positive or negative response to a medication. In brain injury medicine, medications are often used to augment cognitive or physical rehabilitation by increasing alertness, attention, focus, concentration, improving sleep, decreasing agitation, or easing spasticity and rigidity. Rehabilitation nurses not only should be aware of how medications work but also how medications may work differently in a chronically ill or disabled population. This article describes a 51-year-old man who suffered a hypoxic ischemic brain injury and how his neurological complications were managed with a nonbenzodiazepine medication which the Food and Drug Administration approved for the treatment of insomnia.
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http://dx.doi.org/10.1002/rnj.232 | DOI Listing |
Clinics (Sao Paulo)
January 2025
Department of Pediatrics, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea. Electronic address:
Introduction: This study aimed to investigate the associations among seizures, clinical characteristics, and brain injury on Magnetic Resonance Imaging (MRI) in infants with Hypoxic Ischemic Encephalopathy (HIE), and to determine whether these findings can predict unfavorable neurodevelopmental outcomes.
Method: Clinical and electrographic seizures were assessed by amplitude-integrated electroencephalogram, and the extent of brain injury was evaluated by using MRI. At 12‒24 months of age, developmental impairment or death was assessed.
Mol Med Rep
March 2025
Department of Neonatology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China.
Following the publication of this paper, it was drawn to the Editor's attention by a concerned reader that the IL‑1 protein data shown in the western blotting data in Fig. 5A on p. 1905, the hippocampal images shown in Fig.
View Article and Find Full Text PDFEur J Pediatr
January 2025
Neonatology Department. Hospital Sant Joan de Déu, Center for Maternal Fetal and Neonatal Medicine. Neonatal Brain Group, Universitat de Barcelona. Hospital Clínic, Universitat de Barcelona. BCNatal - Barcelona, Institut de Recerca Sant Joan de Déu, Barcelona, Spain.
Purpose: Perinatal hypoxic-ischemic encephalopathy (HIE) is a significant cause of neonatal brain injury. Therapeutic hypothermia (TH) is the standard treatment for term neonates, but its safety and efficacy in neonates < 36 weeks gestational age (GA) remains unclear. This case series aimed to evaluate the outcomes of preterm infants with HIE treated with TH.
View Article and Find Full Text PDFInt J Biol Sci
January 2025
Department of Neonatology and Pediatric Intensive Care, Children's Hospital University of Bonn, Bonn, Germany.
Biomol Biomed
December 2024
Department of Pediatrics, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Hypoxic-ischemic brain injury (HIBD) is a major cause of neonatal mortality and long-term neurological deficits, with limited treatment options. Extracellular vesicles (EVs) from human umbilical cord mesenchymal stem cells (hUC-MSC-EVs) have shown promise in neuroprotection, but the mechanisms remain unclear. This study explores how hUC-MSC-EVs protect neonatal rats from HIBD.
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