New Developments in Blastomycosis.

Semin Respir Crit Care Med

Division of Infectious Diseases, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.

Published: October 2015

Blastomyces dermatitidis, the etiologic agent of blastomycosis, is a thermally dimorphic fungus that grows as a filamentous mold in the environment and as budding yeast in human tissue. This pathogen is endemic to North America, particularly in the states bordering the Mississippi and Ohio rivers, the Great Lakes, and the St. Lawrence Seaway. Infection with B. dermatitidis causes a broad array of clinical manifestations ranging from asymptomatic infection to fulminant sepsis with acute respiratory distress syndrome and death. B. dermatitidis can infect almost any organ in the body, but has a predilection for lungs and skin. There have been recent advances in the understanding of the pathogenesis, diagnosis, and treatment of this fungus. The Infectious Diseases Society of America published updated guidelines in 2008 to guide clinicians in the treatment of this important pathogen.

Download full-text PDF

Source
http://dx.doi.org/10.1055/s-0035-1562898DOI Listing

Publication Analysis

Top Keywords

developments blastomycosis
4
blastomycosis blastomyces
4
blastomyces dermatitidis
4
dermatitidis etiologic
4
etiologic agent
4
agent blastomycosis
4
blastomycosis thermally
4
thermally dimorphic
4
dimorphic fungus
4
fungus grows
4

Similar Publications

A case of disseminated blastomycosis in New England.

IDCases

December 2024

University of Vermont, Department of Biomedical and Health Sciences, Burlington, VT, United States.

infections are classified as dimorphic fungal infections commonly seen geographically throughout the Mississippi and Ohio River Valleys, St. Laurence Seaways, as well as the Canadian providences of Ontario Manitoba, and Saskatchewan. Although primarily endemic in the Midwestern United States, there has been a rise in cases throughout New England.

View Article and Find Full Text PDF

Background: Itraconazole (ICZ) has been approved by the FDA to treat many fungal infections including, blastomycosis, histoplasmosis, and aspergillosis. ICZ can be also used as prophylaxis in the population who are at high risk for developing systemic fungal infections, such as HIV patients, and chemotherapy patients.

Aim: However, since ICZ is a BCS Class II drug that has low solubility and high permeability, leads to low oral bioavailability.

View Article and Find Full Text PDF

[Differential analysis of intestinal flora in patients with hepatic blastomycosis based on second-generation sequencing].

Zhonghua Yu Fang Yi Xue Za Zhi

January 2025

Department of Basic Medicine, College of Medicine, Qinghai University, Xining810016, China.

Exploring the variability of the intestinal flora of patients with hepatic blastocysticercosis and searching for members of the intestinal microflora that may play a role in the disease process by means of macro-genome sequencing technology. A case-control study was used to include fecal samples from patients with hepatic vesicular schistosomiasis admitted to Qinghai Provincial People's Hospital between October 2023 and January 2024 and individuals attending health checkups. The experimental group (AE group) consisted of 10 patients with liver vesicular schistosomiasis and the control group (NC group) consisted of 9 individuals attending health checkups.

View Article and Find Full Text PDF

Outcomes Associated With Blastomycosis in Solid Organ and Hematopoietic Cell Transplant Recipients.

Transpl Infect Dis

December 2024

Department of Medicine, Section of Infectious Diseases, Mayo Clinic, Rochester, Minnesota, USA.

Introduction: With reports of expanding epidemiology of blastomycosis across the United States, the purpose of this study was to evaluate the incidence and outcomes associated with blastomycosis in solid organ transplant (SOT) and hematopoietic cell transplant (HCT) recipients.

Methods: We conducted a retrospective case series of adult SOT and HCT recipients at a tertiary care medical center between January 1, 2005 and September 30, 2023. Cases were defined as culture-proven blastomycosis.

View Article and Find Full Text PDF

Diagnosis of Human Endemic Mycoses Caused by Thermally Dimorphic Fungi: From Classical to Molecular Methods.

J Fungi (Basel)

September 2024

Infectious and Tropical Diseases Research Group (e-INTRO), Biomedical Research Institute of Salamanca-Research Centre for Tropical Diseases at the University of Salamanca (IBSAL-CIETUS), Faculty of Pharmacy, University of Salamanca, 37007 Salamanca, Spain.

Article Synopsis
  • Human endemic mycoses are serious fungal infections that can change their form in response to heat, posing risks to both healthy and immunocompromised individuals.
  • Diagnosing these infections is challenging due to overlapping symptoms, limited traditional diagnostic methods, and lack of access to reliable testing in affected regions.
  • The review discusses key information about these fungi, traditional diagnostic techniques, their pros and cons, and the need for improved diagnostic strategies to lessen the health impact in endemic areas.
View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!