Combination with redox modulators can potentiate the anticancer activity and maximize the selectivity of organometallic complexes with redox-based mechanisms of action. We show that nontoxic doses of l-buthionine sulfoximine increase the selectivity of organo-Os complex FY26 for human ovarian cancer cells versus normal lung fibroblasts to 63-fold. This increase is not due to changes in the mechanism of action of FY26 but to the decreased response of cancer cells to oxidative stress.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4601049 | PMC |
| http://dx.doi.org/10.1021/acs.jmedchem.5b00655 | DOI Listing |
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