AI Article Synopsis
- The study highlights how bantam microRNA plays a crucial role in regulating the number and growth of neuroblasts in the Drosophila central brain.
- Bantam microRNA also helps in the proliferation of intermediate neural progenitor cells within specific neuroblast lineages.
- Key stem cell factors, brat and prospero, are identified as targets of bantam, indicating that bantam influences multiple regulatory steps in neuroblast maintenance and brain growth.
Article Abstract
Post-transcriptional regulation of stem cell self-renewal by microRNAs is emerging as an important mechanism controlling tissue homeostasis. Here, we provide evidence that bantam microRNA controls neuroblast number and proliferation in the Drosophila central brain. Bantam also supports proliferation of transit-amplifying intermediate neural progenitor cells in type II neuroblast lineages. The stem cell factors brat and prospero are identified as bantam targets acting on different aspects of these processes. Thus, bantam appears to act in multiple regulatory steps in the maintenance and proliferation of neuroblasts and their progeny to regulate growth of the central brain.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4647215 | PMC |
| http://dx.doi.org/10.1242/dev.127209 | DOI Listing |
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