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Lifelong consumption of trans fatty acids promotes striatal impairments on Na(+)/K(+) ATPase activity and BDNF mRNA expression in an animal model of mania. | LitMetric

Lifelong consumption of trans fatty acids promotes striatal impairments on Na(+)/K(+) ATPase activity and BDNF mRNA expression in an animal model of mania.

Brain Res Bull

Programa de Pós-Graduação em Farmacologia, Universidade Federal de Santa Maria (UFSM), RS, Brazil; Programa de Pós-Graduação em Bioquímica Toxicológica, UFSM, RS, Brazil. Electronic address:

Published: September 2015

AI Article Synopsis

  • The study investigates the harmful effects of consuming processed foods high in trans fats on brain membranes and their functions in rats.
  • Male rats fed a hydrogenated vegetable fat diet, rich in trans fatty acids, showed changes in brain chemistry and impaired Na+/K+ ATPase activity when subjected to a mania-inducing experiment.
  • The findings suggest that long-term trans fat consumption may contribute to neuropsychiatric disorders like bipolar disorder by increasing oxidative stress and affecting brain-derived neurotrophic factor (BDNF) levels.

Article Abstract

Purpose: To evaluate the toxicity of chronic consumption of processed foods that are rich in trans fat on the lipid composition of brain membranes, as well as its functional repercussions.

Methods: A second generation of male rats born from mothers and grandmothers supplemented with soybean oil (SOC, an isocaloric control group) or hydrogenated vegetable fat (HVF, rich in TFA) (3g/kg; p.o.) were kept under oral treatment until 90 days of age, when they were exposed to an AMPH-induced model of mania.

Results: The HVF group presented 0.38% of TFA incorporation in the striatum, affecting Na(+)/K(+) ATPase activity, which was decreased per se and following AMPH-exposure. The HVF group also showed increased protein carbonyl (PC) and brain-derived neurotrophic factor (BDNF) mRNA levels after AMPH administration, while these oxidative and molecular changes were not observed in the other experimental groups. Additionally, a negative correlation between striatal Na(+)/K(+) ATPase activity and PC levels (r(2)=0.49) was observed.

Conclusion: The prolonged consumption of trans fat allows TFA incorporation and increases striatal oxidative status, thus impairing the functionality of Na(+)/K(+)-ATPase and affecting molecular targets as BDNF mRNA. We hypothesized that the chronic intake of processed foods (rich in TFA) facilitates the development of neuropsychiatric diseases, particularly bipolar disorder.

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Source
http://dx.doi.org/10.1016/j.brainresbull.2015.09.005DOI Listing

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