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mTOR in health and in sickness. | LitMetric

mTOR in health and in sickness.

J Mol Med (Berl)

Biozentrum, University of Basel, 4056, Basel, Switzerland.

Published: October 2015

AI Article Synopsis

Article Abstract

Target of rapamycin (TOR) is a highly conserved protein kinase that plays a key role in mediating cell growth and homeostasis. It is activated by nutrients, growth factors, and cellular energy levels to control a number of anabolic and catabolic processes. It is a validated drug target implicated in a variety of diseases. In this review, we describe the molecular mode of action of TOR in the context of cellular and organismal physiology. We focus on mammalian TOR (mTOR) signaling in cancer and neurological disease and discuss usage of TOR inhibitors in the clinic.

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00109-015-1326-7DOI Listing

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