Stability of enalapril repackaged into monitored dosage system.

Curr Med Res Opin

a Clinical Pharmacy and Pharmacotherapy Unit, Department of Pharmacy and Pharmaceutical Technology , Faculty of Pharmacy, University of Barcelona, Barcelona , Spain.

Published: May 2016

A monitored dosage system (MDS) is a professionally prepared blister-type repackaging system used to improve medication adherence. The objective of this study was to determine the stability of enalapril tablets, a widely prescribed drug, commonly used by the elderly but potentially unstable in MDSs. No degradation of enalapril tablets repackaged into MDSs was observed during the 60 day study period.

Download full-text PDF

Source
http://dx.doi.org/10.1185/03007995.2015.1080674DOI Listing

Publication Analysis

Top Keywords

stability enalapril
8
monitored dosage
8
dosage system
8
enalapril tablets
8
enalapril repackaged
4
repackaged monitored
4
system monitored
4
system mds
4
mds professionally
4
professionally prepared
4

Similar Publications

Importance: Angiotensin receptor-neprilysin inhibition (ARNI) improves mortality among patients with heart failure with reduced ejection fraction (HFrEF), ie, those with an EF of 40% or less.

Objective: To describe national longitudinal trends in ARNI prescribing patterns among hospitalized patients with HFrEF.

Design, Setting, And Participants: Using data from the Get With The Guidelines-Heart Failure (GWTG-HF) registry, hospitalized patients with HFrEF at 614 participating hospitals were identified.

View Article and Find Full Text PDF

This publication is the first to report current, global, pediatric oral extemporaneous compounding practices. Complete survey responses were received from 479 participants actively involved in compounding across all the World Health Organization (WHO) regions. The survey addressed oral formulation of extemporaneous liquids, including the use of commercial or in-house vehicles, flavoring excipients, source of formulation recipes, and beyond use dates (BUDs).

View Article and Find Full Text PDF

Characterization of Liquid Dosage Forms of Atenolol and Enalapril Maleate for Oral and Enteral Feeding Administration.

Pharmaceuticals (Basel)

August 2024

Associated Laboratory for Green Chemistry (LAQV) of the Network of Chemistry and Technology (REQUIMTE), Laboratory of Bromatology and Hydrology, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal.

Article Synopsis
  • Limited pharmaceutical options for cardiovascular treatments in children and the elderly necessitate customized compounded medications for accurate dosing and adherence.
  • This study evaluated the stability and properties of atenolol and enalapril maleate formulations using a unique oral vehicle called SuspendIt, focusing on factors such as palatability, pH, and injectability.
  • Results showed that the atenolol formulation remained stable for 180 days, while enalapril maleate was stable for 90 days at room temperature and 180 days when stored at a cooler temperature.
View Article and Find Full Text PDF

Objective: To explore the relationship between controlling the development of H-type hypertension and the effectiveness of precision prevention of cardiovascular risk.

Methods: 518 patients with essential hypertension with hyperhomocysteinemia diagnosed in December 2019 to February 2020 in Qingyuan District Public Hospital were recruited as the experimental sample for prospective analysis and were equally divided into control and experimental groups according to their order of admission, i.e.

View Article and Find Full Text PDF
Article Synopsis
  • In the PARAGLIDE-HF trial, sacubitril/valsartan showed better results than valsartan alone in reducing NT-proBNP levels in patients with ejection fraction over 40% after heart failure, but increased instances of symptomatic hypotension (SH) were noted.
  • Of the 466 patients studied, 19.7% experienced SH, with a higher occurrence in those treated with sacubitril/valsartan compared to valsartan, though the timing of SH events was similar in both groups.
  • Patients with SH were more likely to be white, have lower baseline systolic blood pressure, and have a higher left ventricular ejection fraction, but the drug's effectiveness in lowering NT-proBNP
View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!