We introduce a set of integrated interaction techniques to interpret and interrogate dimensionality-reduced data. Projection techniques generally aim to make a high-dimensional information space visible in form of a planar layout. However, the meaning of the resulting data projections can be hard to grasp. It is seldom clear why elements are placed far apart or close together and the inevitable approximation errors of any projection technique are not exposed to the viewer. Previous research on dimensionality reduction focuses on the efficient generation of data projections, interactive customisation of the model, and comparison of different projection techniques. There has been only little research on how the visualization resulting from data projection is interacted with. We contribute the concept of probing as an integrated approach to interpreting the meaning and quality of visualizations and propose a set of interactive methods to examine dimensionality-reduced data as well as the projection itself. The methods let viewers see approximation errors, question the positioning of elements, compare them to each other, and visualize the influence of data dimensions on the projection space. We created a web-based system implementing these methods, and report on findings from an evaluation with data analysts using the prototype to examine multidimensional datasets.
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http://dx.doi.org/10.1109/TVCG.2015.2467717 | DOI Listing |
Proc Natl Acad Sci U S A
January 2025
Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210.
The homo-dodecameric ring-shaped RNA binding attenuation protein (TRAP) from binds up to twelve tryptophan ligands (Trp) and becomes activated to bind a specific sequence in the 5' leader region of the operon mRNA, thereby downregulating biosynthesis of Trp. Thermodynamic measurements of Trp binding have revealed a range of cooperative behavior for different TRAP variants, even if the averaged apparent affinities for Trp have been found to be similar. Proximity between the ligand binding sites, and the ligand-coupled disorder-to-order transition has implicated nearest-neighbor interactions in cooperativity.
View Article and Find Full Text PDFJ Neurosurg
January 2025
13Department of Neurosurgery, Shimane Prefectural Central Hospital, Shimane, Japan.
Objective: Aneurysmal subarachnoid hemorrhage (SAH) is associated with high morbidity and mortality rates. In particular, functional outcomes of SAH caused by large or giant (≥ 10 mm) ruptured intracranial aneurysms are worsened by high procedure-related complication rates. However, studies describing the risk factors for poor functional outcomes specific to ruptured large/giant aneurysms are sparse.
View Article and Find Full Text PDFJ Occup Environ Med
January 2025
Department of Biostatistics, Florida International University, Miami, FL, United States.
Objective: To assess factors influencing Neonatal Respiratory Distress Syndrome (RDS) risk, incorporating maternal demographics, behaviors, medical conditions, pregnancy-related factors, and PM2.5 speciation pollutants exposures.
Methods: Using Florida de-identified birth records, logistic regression analyses were conducted to assess associations between maternal exposure to PM2.
Otol Neurotol
February 2025
Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
Background Introduction: Vestibular schwannoma (VS) tumors typically present with sensorineural hearing loss (SNHL). Losartan has recently demonstrated prevention of tumor-associated SNHL in a mouse model of VS through suppression of inflammatory and pro-fibrotic factors, and the current study investigates this association in humans.
Methods: This is a retrospective study of patients with unilateral VS and hypertension followed with sequential audiometry at a tertiary referral hospital from January 1994 to June 2023.
PLoS Pathog
January 2025
Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington, United States of America.
Host-pathogen interactions represent a dynamic evolutionary process, wherein both hosts and pathogens continuously develop complex mechanisms to outmaneuver each other. Borrelia burgdorferi, the Lyme disease pathogen, has evolved an intricate antigenic variation mechanism to evade the host immune response, enabling its dissemination, persistence, and pathogenicity. Despite the discovery of this mechanism over two decades ago, the precise processes, genetic elements, and proteins involved in this system remain largely unknown.
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