AI Article Synopsis
- Tobacco smoke (TS) is linked to chronic bronchitis (CB), but the underlying mechanisms remain unclear; a study on rats was conducted to investigate these mechanisms through metabolic profiling.
- Researchers utilized liquid chromatography-mass spectrometry (LC-MS) to analyze serum from rats with CB, identifying 11 potential biomarkers and showing significant changes in lipid and amino acid metabolism in the TS group compared to controls.
- The study found elevated levels of certain lysophosphatidylethanolamines in the TS group, suggesting they could serve as biomarkers for CB, and highlighted that metabolomics is a valuable tool for understanding and diagnosing TS-induced chronic bronchitis.
Article Abstract
Tobacco smoke (TS) is a major causative agent to lead to chronic bronchitis (CB). However the mechanisms of CB induced by TS are unclear. In this report, rats were exposed to different concentrations of TS and the metabolic features of CB were characterized by using a nontargeted metabolic profiling method based on liquid chromatography-mass spectrometry (LC-MS) to detect the altered metabolic patterns in serum from CB rats and investigate the mechanisms of CB. 11 potential biomarkers were identified in serum of rats. Among them, the levels of lysophosphatidylethanolamine (18:1), lysophosphatidic acid (18:1), lysophosphatidylethanolamine (18:0), lysophosphatidylethanolamine (16:0), lysophosphatidylethanolamine (20:4), docosahexaenoic acid, 5-hydroxyindoleacetic acid and 5'-carboxy-γ-tocopherol were higher in TS group compared to control group. Conversely, the levels of 4-imidazolone-5-propionic acid, 12-hydroxyeicosatetraenoic acid and uridine were lower in TS group. The results indicated that the mechanism of CB was related to amino acid metabolism and lipid metabolism, particularly lipid metabolism. In addition, lysophosphatidylethanolamines were proved to be important mediators, which could be used as biomarkers to diagnose CB. These results also suggested that metabolomics was suitable for diagnosing CB and elucidating the possible metabolic pathways of TS-induced CB.
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| http://dx.doi.org/10.1002/bmc.3620 | DOI Listing |
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