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Analyzing the adverse events of NK-1 receptor antagonists: a pharmacovigilance study from the FAERS database.
Sci Rep
December 2024
Department of Pharmacy, Suzhou Research Center of Medical School, Suzhou Hospital, Affiliated Hospital of Medical School, Nanjing University, Suzhou, 215153, China.
Background: NK-1 receptor antagonists (NK-1RAs) are proven to be successful in preventing chemotherapy-induced nausea and vomiting (CINV). The safety profile of NK-1RAs has not been systematically analyzed in the real world. This pharmacovigilance study investigated the differences in adverse events (AEs) between NK-1RAs.
View Article and Find Full Text PDFFirst documented case of Smith-Lemli-Opitz syndrome in Syria: clinical presentation, diagnosis, and experimental management with simvastatin.
Oxf Med Case Reports
November 2024
Department of Otorhinolaryngology, Al Mouwasat University Hospital, Faculty of Medicine, Damascus University, Damascus, Syria.
Article Synopsis
- Smith-Lemli-Opitz syndrome (SLOS) is a rare genetic disorder that disrupts cholesterol synthesis, leading to a range of physical and mental developmental issues.
- A case study focuses on a 25-day-old male infant with congenital anomalies like microcephaly and syndactyly, alongside serious symptoms such as severe vomiting, irritability, and dehydration.
- Laboratory tests confirmed low serum cholesterol and a genetic diagnosis of SLOS, with treatment involving simvastatin leading to improved symptoms; this case is notable as the first documented instance of SLOS in Syria.
Nutmeg Poisoning With Electrolyte Abnormalities: A Case Report.
Cureus
October 2024
Department of Dermatology, Sakura Medical Center, Toho University, Sakura, Sakura, JPN.
Nutmeg is a commonly used spice that contains myristicin, a compound with anticholinergic and psychoactive properties. Excessive consumption can lead to toxicity, causing psychiatric and anticholinergic symptoms such as tachycardia, dizziness, dry mouth, tremors, and nausea. Nutmeg poisoning is rare and not widely recognized.
View Article and Find Full Text PDFFlecainide acetate is classified as a class IC antiarrhythmic medication according to the Vaughan-Williams classification, primarily used to manage both ventricular and supraventricular tachycardia. It is commonly employed for pharmacological cardioversion of atrial fibrillation (AF) and is frequently used in the "pill-in-the-pocket" approach for on-demand rhythm control. Despite its efficacy, flecainide is associated with significant adverse effects, including cardiac arrest, dysrhythmias, and heart failure.
View Article and Find Full Text PDFOsmotic demyelination syndrome: revisiting the diagnostic criteria through two fatal cases.
BMC Neurol
November 2024
Department of Anatomical, Histological, Forensic and Orthopedic Sciences, "Sapienza" University of Rome, Rome, 00185, Italy.
Background: Osmotic Demyelination Syndrome (ODS) encompasses Central Pontine Myelinolysis and Extrapontine Myelinolysis, both of which are serious neurological conditions linked to the overly rapid correction of hyponatremia. Despite growing evidence, the exact etiology of ODS remains incompletely understood. The present paper describes two case studies, aiming to provide a comprehensive overview of the pathological findings and clinical outcomes associated with ODS.
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