Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741540 | PMC |
| http://dx.doi.org/10.18632/oncotarget.5720 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Fiber density and matrix stiffness modulate distinct cell migration modes in a 3D stroma mimetic composite hydrogel.
Acta Biomater
June 2023
Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, 48109, United States; Department of Chemical Engineering, University of Michigan, Ann Arbor, MI, 48109, United States. Electronic address:
Article Synopsis
- The peritumoral stroma influences how cancer cells migrate during metastasis, with various biophysical and biochemical cues impacting their movement and survival, leading to differences in their ability to spread and resist treatments.
- In this study, researchers created a synthetic stromal model to explore how changes in matrix density and mechanics affect the migration behaviors of MCF10A cells, a type of cancer cell, including modes like amoeboid and mesenchymal movement.
- The findings suggest that specific matrix conditions can promote certain migration types, which affects how well cancer cells resist apoptosis (programmed cell death), highlighting the importance of the stromal microenvironment in developing cancer therapies that target these adaptive behaviors.
Transition From Military Prehospital Medicine to Civilian EMS.
Mil Med
September 2020
National Association of Emergency Medical Technicians, 132-A East Northside Dr, Clinton, MS 39056.
Introduction: Currently, there is a disconnection between veteran military medics and the civilian Emergency Medical Services (EMS) workforce. This project aimed to characterize the rate of civilian certification among military medics, both active duty and retired, and identify perceived barriers to continuing a career in EMS after military separation.
Materials And Methods: The National Association of Emergency Medical Technicians (EMTs) administered a 21-question online survey to participants.
The potential role of platelets in the consensus molecular subtypes of colorectal cancer.
Cancer Metastasis Rev
June 2017
Department of Gastrointestinal Medical Oncology, M. D. Anderson Cancer, Unit 0426, 1515 Holcombe Boulevard, Houston, TX, 77030, USA.
The consensus molecular subtypes (CMS) in colorectal cancer (CRC) represent distinct molecular subcategories of disease as reflected by comprehensive molecular profiling. The four CMS subtypes represent unique biology. CMS1 represents high immune infiltration.
View Article and Find Full Text PDFTransforming growth factor (TGF) β and Smad signalling pathways: A likely key to EMT-associated COPD pathogenesis.
Respirology
January 2017
NHMRC Centre of Research Excellence for Chronic Respiratory Disease, School of Medicine, University of Tasmania, Hobart, Tasmania, Australia.
Background And Objective: COPD is characterized by poorly reversible airflow obstruction usually due to cigarette smoking. Transforming growth factor (TGF)-β1 has been implicated in the pathogenesis of COPD, and in particular a process called epithelial mesenchymal transition (EMT), which may well be an intermediatory between smoking and both airway fibrosis and lung cancer. The downstream classical or 'canonical' TGF-β1 pathway is via the phosphorylated (p) Smad transcription factor system.
View Article and Find Full Text PDFThe Role of Cancer Stem Cells in Recurrent and Drug-Resistant Lung Cancer.
Adv Exp Med Biol
May 2016
Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, 48201, USA.
Lung cancer is the leading cause of cancer-related deaths worldwide with a 5-year overall survival rate of less than 20 %. Considering the treatments currently available, this statistics is shocking. A possible explanation for the disconnect between sophisticated treatments and the survival rate can be related to the post-treatment enrichment of Cancer Stem Cells (CSCs), which is one of a sub-set of drug resistant tumor cells with abilities of self-renewal, cancer initiation, and further maintenance of tumors.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!