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Children With Sydenham Chorea and Psychiatric Disorders Had Variable Long-Term Outcomes and Required Multidisciplinary Management.
Acta Paediatr
January 2025
Department of Health and Wellbeing, University of Glasgow, Glasgow, UK.
Aim: Sydenham chorea (SC) is a globally significant, post-streptococcal, childhood neuropsychiatric condition that is rare in western Europe. This retrospective single-centre study focused on children with neuropsychiatric features of SC.
Methods: Participants were recruited from neuropsychiatry referrals to a regional paediatric neurology department in Glasgow, Scotland, from 2009 to 2012.
The Genetic Causal Effect of Autoimmune Diseases on pan-Cancers: Evidence from Mendelian Randomization.
J Cancer
January 2025
Department of Spinal Surgery, Tianjin Union Medical Center, Tianjin, China.
Whether autoimmune diseases caused any effects on the risk of cancers remained yet clarified. This study aimed to investigate the causal effect of autoimmune diseases on pan-cancers through mendelian randomization (MR) analysis. The GWAS summary datasets of 10 autoimmune diseases were derived from the IEU or UK biobank website.
View Article and Find Full Text PDFAuto-Immune Diseases, Head and Neck Trauma, and Smoking Are Strong Predictors of Multiple Sclerosis.
Iran J Public Health
September 2024
Department of Epidemiology, Shiraz University of Medical Sciences, Shiraz, Iran.
Background: Several health, environmental, and lifestyle-related factors have been separately linked to multiple sclerosis (MS) by different studies. However, these studies did not adequately account for the temporal association of these factors with MS while considering the influence of other variables in the analysis. A comprehensive investigation of these factors remains scarce.
View Article and Find Full Text PDFLong-term follow-up MR imaging in children with transverse myelitis.
Mult Scler Relat Disord
December 2024
Department of Pediatric Neurology, Children´s Hospital Datteln, University Witten/Herdecke, Dr. Friedrich-Steiner Str. 5, Datteln D-45711, Germany.
Article Synopsis
- The study investigates how lesions in children with transverse myelitis (TM) resolve over time, focusing on different related diseases: MOG-antibody associated disorders (MOGAD), multiple sclerosis (MS), neuromyelitis optica spectrum disorders (NMOSD), and double seronegative TM.
- A total of 78 children from various medical centers were assessed, and a grading system was used to measure the resolution of lesions over time.
- Results showed that MOGAD had the fastest and most complete resolution of lesions, followed by double seronegative TM, MS, and NMOSD, with none of the NMOSD patients achieving complete resolution during the observation period.
Blood culture-negative endocarditis with large vegetation and the role of bronchoalveolar lavage: a case report.
Eur Heart J Case Rep
October 2024
Hôpital du Valais, Service de Cardiologie, Avenue Grand-Champsec 80, 1951 Sion, Switzerland.
Article Synopsis
- - Blood culture-negative endocarditis (BCNE) occurs alongside conditions like sepsis and autoimmune diseases, and can lead to significant cardiac issues due to bacterial vegetation; common pathogens include certain types of
- Enterococcus
- and
- Streptococcus
- species.
- - A 60-year-old man with severe aortic stenosis and chronic infections was diagnosed with BCNE, confirmed through imaging and subsequent surgery, which involved replacing the affected valve after identifying a chronic infection via bronchoalveolar lavage (BAL).
- - The case highlights the importance of BAL cultures in diagnosing BCNE when traditional sputum tests are negative and underscores the need for ongoing antibiotic therapy post-surgery for successful recovery.
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