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Oncologic reconstructive surgery of the talus with structural allograft: Case report.
Int J Surg Case Rep
December 2024
Orthopedics and traumatology UNAB, Floridablanca, Colombia. Electronic address:
Introduction And Importance: Introduction and importance: Bone tumors of the foot constitute 3 % of all bone tumors, within these, the location in the talus constitutes between 8 and 23 % of bone tumors. Within the oncological management of these lesions, preservation surgery has had a great boom in the last 10 years, however, the use of massive structural allograft is not a conventional surgery and there is little literature on its use, which is why we consider important to document clinical cases.
Case Presentation: we document 2 clinical cases of bone tumor in the talus that were surgically managed with tumor resection plus reconstruction with total and partial talus allograft.
Thermosensitive hydrogel delivery of BCG lysates and tumor antigens: A novel strategy for melanoma immunoprevention and therapeutics.
Biochem Biophys Res Commun
December 2024
Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China. Electronic address:
Melanoma, recognized as one of the most aggressive forms of skin cancer, continues to show a steady rise in global incidence. While Bacillus Calmette-Guérin (BCG) has been identified as a potential intralesional therapy for melanoma, its therapeutic efficacy remains suboptimal. This study introduces a novel thermosensitive hydrogel formulated with BCG lysates and either OVA peptide or tumor cell lysates (PPP-BCG-OVA/TL).
View Article and Find Full Text PDFPathological-microenvironment responsive injectable GelMA hydrogel with visualized biodegradation for pressure-assisted treatment of hypertrophic scars.
Int J Biol Macromol
December 2024
Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology (HUST), Wuhan 430022, China; Hubei Engineering Research Center for Skin Repair and Theranostics, Wuhan 430022, China. Electronic address:
Intralesional injection of 5-fluorouracil for the clinical treatment of hypertrophic scars (HS) remains challenging due to its short half-life, as well as the absence of evidence-based dosage and frequency injection guidelines. Herein, we developed a matrix metalloproteinases (MMPs)/reactive oxygen species (ROS)-responsive injectable prodrug hydrogel (GFP) that exhibits sustained drug release and fluorescence imaging capability, aiming to facilitate the optimization of injection dosage and frequency in HS treatment. The GFP hydrogel comprises gelatin methacryloyl and pendant methacryloyl-decorated tetrapeptide (PPPK) with 5-fluorouracil acetic acid/rhodamine B at the N-terminus.
View Article and Find Full Text PDFA Unique Case of Infected Laryngeal Tophi With Underlying Gout.
Cureus
November 2024
Otolaryngology - Head and Neck Surgery, Hospital Queen Elizabeth, Kota Kinabalu, MYS.
Gout is a disorder of purine metabolism described by the deposition of monosodium urate crystals with rare involvement in the head and neck. This is the first laryngeal gout case reported in Sabah, Malaysia. A 50-year-old gentleman with a long history of gouty arthritis presented with acute painless anterior neck swelling for two weeks.
View Article and Find Full Text PDFDissecting Cellulitis Presenting After Hair Restoration Surgery.
Cureus
November 2024
Dermatology, Hospital Universitario "Dr. José Eleuterio González", Nuevo León, MEX.
Dissecting cellulitis (DC) of the scalp is a chronic inflammatory condition marked by neutrophilic cicatricial alopecia, often linked to staphylococcal antigens. This case report details a 34-year-old male with scarring acne who developed DC following follicular unit extraction (FUE) approximately four months prior. Trichoscopic examination revealed brown pigmented dots, erythema, and melicerous crusts.
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