AI Article Synopsis
- Most small cell lung cancer (SCLC) patients experience relapse and have a low survival rate despite initially responding to treatment; this study aims to identify factors impacting relapse and the relationship between progression-free survival (PFS) and overall survival (OS).
- The research analyzed clinical data from 182 SCLC patients who underwent chemotherapy and possibly radiotherapy, focusing on various factors that could affect PFS, such as the TNM stage and presence of metastases.
- Findings indicate that increasing the number of first-line chemotherapy cycles, achieving a better initial response, and using thoracic radiotherapy can improve PFS, with a significant positive correlation found between PFS and OS.
Article Abstract
Background And Objective: Most small cell lung cancer (SCLC) patients relapse or progress and have low survival rate although they have significant response to initial chemotherapy and radiotherapy. This study intends to explore the factors affecting the relapse (or progression) of nonoperative SCLC and to explore the correlations between progression-free survival (PFS) and overall survival (OS).
Methods: Clinical data of 182 patients diagnosed with SCLC between January 2009 and December 2011 at Shanghai Chest Hospital has been reviewed and retrospectively analyzed. All of these patients accepted chemotherapy combined (or not combined) with radiotherapy, and relapsed or progressed after first-line therapy. Univariate Kaplan-Meier survival estimates as well as multivariate Cox regression survival analysis were used to locate the potential factors affecting PFS. The correlation between PFS and OS was analyzed via Bivariate Correlation Analysis method.
Results: The univariate estimates showed that the TNM stage, liver metastasis or not, brain metastasis or not, first-line chemotherapy cycles, effect of initial chemotherapy, and thoracic radiotherapy combined or not were the significant contributive factors to PFS. In the subgroup of the patients without brain metastases, those received prophylactic cranial irradiation (PCI) had longer PFS. Cox regression indicated that the three independent variables of first-line chemotherapy cycles, effect of initial chemotherapy and thoracic radiotherapy combined or not were closely related to PFS. In addition, significant positive correlation between PFS and OS had been observed.
Conclusions: PFS could be prolonged by having more first-line chemotherapy cycles (>4 cycles), obtaining better effect of initial chemotherapy (partial response or complete response), combining with thoracic radiotherapy and implementing PCI for patients without brain metastasis.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6000111 | PMC |
| http://dx.doi.org/10.3779/j.issn.1009-3419.2015.09.01 | DOI Listing |
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