Biomimetic nanoassembly for targeted antigen delivery and enhanced Th1-type immune response.

Chem Commun (Camb)

Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resources Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China.

Published: November 2015

A new type of biomimetic nanoassembly for targeted antigen delivery and enhanced Th1-type response is reported for the first time, to combat the major challenges in the treatment of infected cells.

Download full-text PDF

Source
http://dx.doi.org/10.1039/c5cc06794dDOI Listing

Publication Analysis

Top Keywords

biomimetic nanoassembly
8
nanoassembly targeted
8
targeted antigen
8
antigen delivery
8
delivery enhanced
8
enhanced th1-type
8
th1-type immune
4
immune response
4
response type
4
type biomimetic
4

Similar Publications

Biomimetic nanoassemblies derived from natural products are considered promising nanomaterials due to their self-assembling ability and their favorable interactions with biological molecules leading to their numerous applications as therapeutic agents or as molecular probes. In this work, we have created peptide nanoconjugates of two natural products, β-Boswellic acid (BA) and β-glycyrrhetinic acid (GH). Both BA and GH are known for their medicinal value, including their role as strong antioxidants, anti-inflammatory, neuroprotective and as anti-tumor agents.

View Article and Find Full Text PDF

Tailored biomimetic nanoreactor improves glioma chemodynamic treatment via triple glutathione depletion and prompt acidity elevation.

Mater Today Bio

February 2025

Department of Neurosurgery, Research Center of Clinical Medicine, Affiliated Hospital of Nantong University, Nantong University, Nantong, 226001, China.

Chemodynamic therapy (CDT) is an emerging antitumor strategy utilizing iron-initiated Fenton reaction to destroy tumor cells by converting endogenous HO into highly toxic hydroxyl radical (OH). However, the intratumoral overexpressed glutathione (GSH) and deficient acid greatly reduce CDT efficacy because of OH scavenging and decreased OH production efficiency. Even worse, the various physiological barriers, especially in glioma, further put the brakes on the targeted delivery of Fenton agents.

View Article and Find Full Text PDF

Biomimetic Cerium-Assisted Supra-Carbon Dots Assembly for Reactive Oxygen Species-Activated Atherosclerosis Theranostic.

Small

February 2025

Key Laboratory for Biorheological Science and Technology of Ministry of Education, State and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College of Chongqing University, Chongqing University Three Gorges Hospital, Chongqing, 400044, China.

Theranostic applications in atherosclerosis plaque microenvironment-triggered nanoplatforms are significantly compromised by the complex synthesis procedure, non-specific distribution, and limited therapeutic function. Therefore, development of a facile and feasible method to construct a pathology-based stimuli-responsive nanoplatform with satisfactory theranostic performance remains a demanding and highly anticipated goal. Herein, a novel class of multifunctional supra-carbon dots (CDs), denoted as MM@Ce-CDs NPs, by a simple nanoassembly and a subsequent coating with macrophage membrane (MM), is developed for the targeted reactive oxygen species-trigged theranostic and positive regulation of the pathological plaque microenvironment in AS.

View Article and Find Full Text PDF

Bionanoparticles with In Situ Nitric Oxide Release for Precise Modulation of ER-TRPV1 Ion Channels in Multimodal Killing of Glioblastoma.

Small

January 2025

Innovation and Research Institute of Hebei University of Technology in Shijiazhuang, School of Health Sciences and Biomedical Engineering, Hebei University of Technology, Xiping Road, Tianjin, 300130, P. R. China.

Article Synopsis
  • Glioblastoma (GBM) is difficult to treat due to its immunosuppressive environment and resistance to therapies, with the TRPV1 ion channel playing a key role in tumor growth control.
  • A novel approach using a biomimetic nanoassembly (M-UCN-T) is designed to precisely release nitric oxide (•NO) to activate the TRPV1 channels, enhancing treatment effectiveness.
  • By targeting both tumor cells and the endoplasmic reticulum, this method aims to trigger stress pathways in multiple organelles, leading to improved tumor cell destruction.
View Article and Find Full Text PDF

Biomimetic Modification of siRNA/Chemo Drug Nanoassemblies for Targeted Combination Therapy in Breast Cancer.

ACS Appl Mater Interfaces

November 2024

Institute of Molecular Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200217, China.

Article Synopsis
  • Tumor growth involves complex biological processes, and using only one type of treatment (monotherapy) often leads to issues like drug resistance and limited effectiveness.
  • To improve cancer treatment, a combined approach (multitherapy) that incorporates both chemotherapy and oligonucleotide drugs is necessary.
  • Researchers have created advanced multidrug nanoparticles using modified red blood cell membranes to enhance the delivery and effectiveness of targeted treatments for HER2-positive breast cancer, showing promising results.
View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!