Purpose: To investigate the concentration of IL-35 in serum and gingival crevicular fluid (GCF) and the correlation between IL-35 and periodontal clinical parameters, and explore the possible role of IL-35 in chronic periodontitis (CP).
Methods: Twenty patients with moderate or severe chronic periodontitis were selected as experimental group and 20 healthy people were included as control group. The patients' baseline information, probing depth (PD) and clinical attachment level (CAL) were recorded. Their serum and GCF were collected and then the concentration of IL-35 in GCF and serum were detected by ELISA. SPSS19.0 software package was used for statistical analysis.
Results: The concentration of IL-35 in GCF and serum of chronic periodontitis were significantly higher than the control group (P<0.001). There was significant negative correlation between IL-35 and clinical parameters.
Conclusions: Chronic periodontitis may increase the concentration of IL-35 in serum and GCF; IL-35 level is negatively correlated with periodontitis.
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