AI Article Synopsis
- There are two main ideas about how the MYC protein works in cells: one says it boosts all active genes, and the other says it carefully controls specific genes.
- The text argues that the second idea is the best explanation for how MYC operates.
- MYC affects cell functions and might change how RNA is made in the body, and scientists are working to understand all the genes and pathways MYC influences since it plays a big role in causing cancer.
Article Abstract
Two opposing models have been proposed to describe the function of the MYC oncoprotein in shaping cellular transcriptomes: one posits that MYC amplifies transcription at all active loci; the other that MYC differentially controls discrete sets of genes, the products of which affect global transcript levels. Here, we argue that differential gene regulation by MYC is the sole unifying model that is consistent with all available data. Among other effects, MYC endows cells with physiological and metabolic changes that have the potential to feed back on global RNA production, processing and turnover. The field is progressing steadily towards a full characterization of the MYC-regulated genes and pathways that mediate these biological effects and - by the same token - endow MYC with its pervasive oncogenic potential.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1038/nrc3984 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!