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Pivotal role of virulence genes in pathogenicity and vaccine development.
Front Med (Lausanne)
January 2025
Department of Veterinary Preventive Medicine, College of Veterinary Medicine, Qassim University, Buraydah, Saudi Arabia.
One of the most prevalent human infections is (), which affects more than half of the global population. Although infections are widespread, only a minority of individuals develop severe gastroduodenal disorders. The global resistance of to antibiotics has reached concerning levels, significantly impacting the effectiveness of treatment.
View Article and Find Full Text PDFEchoes of Strain: A Two-Year Longitudinal Study on the Impact of China's Zero-COVID Policy on College Students' Insomnia and Depressive Symptoms.
Nat Sci Sleep
January 2025
Faculty of Psychology, Beijing Normal University, Beijing, 100875, People's Republic of China.
Purpose: In China, stringent and long-lasting infection control measures, which were called "dynamic zero-COVID policy", have significantly affected the mental health of college students, particularly concerning depressive and insomnia symptoms. This study aims to investigate how depressive and insomnia symptoms evolved among Chinese college students throughout the pandemic, including the beginning and end of the dynamic zero-COVID policy period.
Patients And Methods: We conducted a 2-years longitudinal survey involving 1102 college students, collecting data at three key time points.
Child Death and Mothers' Subsequent Mental Health in a High-Mortality African Community.
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Partners in Hope, Lilongwe, Malawi.
Despite declines in child mortality rates, experiencing a child death remains a common feature of motherhood in many contemporary African populations. Yet, we lack population insights into the consequences of child death for mothers' well-being in the high-mortality regions where it concentrates. Contrasting an extensive psychology literature on the severe and long-lasting consequences of child death for parents in low-mortality settings, a long-standing thesis in multiple social science literature is that the normativity of child death in high-mortality settings can lead to a numbing effect-muting parents' reactions to child loss.
View Article and Find Full Text PDFMicroenvironmental Regulation of Dormancy in Breast Cancer Metastasis: "An Ally that Changes Allegiances".
Adv Exp Med Biol
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Laboratory of Tumor Heterogeneity, Metastasis and Resistance, Department of Biomedicine, University of Basel, University Hospital Basel, Basel, Switzerland.
Breast cancer remission after treatment is sometimes long-lasting, but in about 30% of cases, there is a relapse after a so-called dormant state. Cellular cancer dormancy, the propensity of disseminated tumor cells (DTCs) to remain in a nonproliferative state for an extended period, presents an opportunity for therapeutic intervention that may prevent reawakening and the lethal consequences of metastatic outgrowth. Therefore, identification of dormant DTCs and detailed characterization of cancer cell-intrinsic and niche-specific [i.
View Article and Find Full Text PDFMitotic chromatin marking governs the segregation of DNA damage.
Nat Commun
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Laboratory of Epigenome Integrity, Epigenetics & Cell Fate Centre, UMR7216 CNRS, Université Paris Cité, Paris, France.
The faithful segregation of intact genetic material and the perpetuation of chromatin states through mitotic cell divisions are pivotal for maintaining cell function and identity across cell generations. However, most exogenous mutagens generate long-lasting DNA lesions that are segregated during mitosis. How this segregation is controlled is unknown.
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