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Novel antidotes for target specific oral anticoagulants. | LitMetric
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Novel antidotes for target specific oral anticoagulants.

Arundhati Das Delong Liu

Exp Hematol Oncol

Department of Medicine, New York Medical College and Westchester Medical Center, Valhalla, NY 10595 USA ; Henan Cancer Hospital and the Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, China.

Published: September 2015

Target specific oral anticoagulants (dabigatran, rivaroxaban, apixaban, and edoxaban) are changing the landscape of anticoagulation. The major drawback is the absence of an effective antidote for severe bleedings and/or prior to procedures. Currently there are a few promising antidotes undergoing clinical trials. This review summarized the latest development in idarucizumab, andexanet alpha and PER977.

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 Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4570637PMC
http://dx.doi.org/10.1186/s40164-015-0020-3DOI Listing

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