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http://dx.doi.org/10.4274/tjh.2015.0202DOI Listing

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Neutrophilic Dermatosis of the Hands: A Case Report.

Acta Dermatovenerol Croat

December 2023

Nooshin Bagherani, MD, PhD, Tehran University of Medical Sciences, Italy Street, Tehran, Iran;

Article Synopsis
  • - Neutrophilic dermatosis of the hands (NDDH) is a recently identified localized variant of Sweet's syndrome, characterized by violaceous papulonodules on the hands, lacking true vasculitis findings, as outlined by Strutton et al. (1996) and Galaria et al. (2000).
  • - A 46-year-old man presented with a painful, ulcerative lesion on his left hand, which started as a small papule and progressively worsened despite various treatments for suspected bacterial or fungal infections.
  • - Upon examination, the lesion measured 4×7 cm and was associated with atrophic scars from previous similar lesions; laboratory tests indicated leukocytosis and altered liver function
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Sweet's syndrome (SS), or acute febrile neutrophilic dermatosis, characteristically presents with fever, dermal neutrophilic infiltrates, and neutrophilia. It typically manifests as tender erythematous plaques; however, various variants are documented, including bullous. Malignancy-associated Sweet's syndrome (MASS) can present as a paraneoplastic syndrome in those with established cancers or with undiagnosed malignancies.

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Background: Ulcerative colitis (UC) is a chronic, relapsing progressive inflammatory immune disease. There is still no cure for it. Even worse, UC may predispose patients to opportunistic infections, and several extra-intestinal manifestations (EIMs) and comorbidities may antedate, occur with, or postdate the onset of UC, which may increase the mortality risk.

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Unlabelled: Sweet's syndrome or acute febrile neutrophilic dermatosis is characterized by an acute inflammatory skin eruption of oedematous and erythematous papules, plaques or nodules, accompanied by fever, and leucocytosis with possible extracutaneous involvement. Aetiologies include infections, inflammatory bowel disease, pregnancy or malignancy, or the syndrome may be drug-induced by many classes of medications or very rarely, radiocontrast exposure. Herein, the authors report a case of radiocontrast-induced bullous Sweet's syndrome and contrast-induced acute kidney injury in a woman in her 60s with a complex medical history.

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