Recently, radiation induced necrosis in the brain has been treated using bevacizumab, an anti-VEGF antibody. We validated the VEGF specificity by comparing the therapeutic efficacy of anti-VEGF with non-specific isotype control antibody. Additionally, we found that VEGF over-expression and RN developed simultaneously, which precludes preventative anti-VEGF treatment.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854530 | PMC |
| http://dx.doi.org/10.1016/j.radonc.2015.09.004 | DOI Listing |
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