AI Article Synopsis
- The recruitment of oligosaccharides and simple sugars in water is currently an unsolved issue in molecular recognition.
- Structure-guided redesign of a β-peptide "borono-bundle" improved its ability to attract simple sugars in neutral water.
- Its strong affinity for fructose (663 M(-1)) suggests potential for selective catalysis, with upcoming research aimed at exploring this application.
Article Abstract
The selective recruitment of oligosaccharides, or even simple sugars, in water solvent is an unsolved molecular recognition problem. Structure-guided, electrostatic redesign led to a significant increase in the affinity of a β-peptide "borono-bundle" for simple sugars in neutral aqueous solution. The affinity for fructose (663 M(-1)) in water should allow its recruitment to the bundle surface for selective catalysis, and future work will focus in this direction.
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| http://dx.doi.org/10.1021/acs.orglett.5b02187 | DOI Listing |
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