This study investigated the variability by considering an action programme as hierarchically organized, which reconciles invariant and variant features of motor skills at the macro- and microstructural level of analysis. It was assumed that invariant aspects of skilled actions express the macrostructure and therefore measures of sequencing, relative size, relative timing, relative force and relative pause time. The microstructure was related to the variant aspects so that total size, total movement time, total force, and total pause time were selected as its measures. These propositions were tested in an experimental design comprised by three learning phases: a stabilisation phase that entailed a given number of trials to achieve the functional stabilization on a graphic task, followed by transfer and retention phases. In the transfer phase, the graphic task was modified to yield different demands upon skill reorganization. Two such modifications demanded parametric changes (i.e. microstructure changes), in which graphic size and drawing speed were altered. Another modification demanded structural alterations (i.e. macrostructure change), in which drawing was changed. Overall, results supported the main predictions by showing that parametric changes in the task affected the microstructure, but did not affect the macrostructure consistently. Furthermore, a structural change affected both macro- and microstructure.
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Healthcare (Basel)
January 2025
Department of Computer Science, Institute of Mathematics and Statistics, University of São Paulo (USP), São Paulo 05508-220, SP, Brazil.
Background/objectives: The aim of this paper was to compare voice and speech characteristics between post-COVID-19 and control subjects. The hypothesis was that acoustic parameters of voice and speech may differentiate subjects infected by COVID-19 from control subjects. Additionally, we expected to observe the persistence of symptoms in women.
View Article and Find Full Text PDFLasers Surg Med
January 2025
Wyant College of Optical Science, University of Arizona, Tucson, Arizona, USA.
Study Objective: We present the results of the first feasibility and safety study of a novel multi-modality falloposcope, in 19 volunteers. The falloposcope incorporated multispectral fluorescence imaging (MFI) and optical coherence tomography (OCT) for evaluation of the fallopian tubes (FT).
Methods: Nineteen females undergoing elective salpingectomy were recruited in this IRB-approved study.
Food Res Int
January 2025
Department of Food Science, Université Laval, Québec G1V 0A6, Canada; Laboratoire de Transformation Alimentaire et Procédés ÉlectroMembranaires (LTAPEM, Laboratory of Food Processing and ElectroMembrane Processes), Université Laval, Québec G1V 0A6, Canada; Institute of Nutrition and Functional Foods (INAF), Université Laval, Québec G1V 0A6, Canada. Electronic address:
Industrial wastewaters are significant global concerns due to their environmental impact. Yet, protein-rich wastewaters can be valorized by enzymatic hydrolysis to release bioactive peptides. However, achieving selective molecular differentiation and eventually enhancing peptide bioactivities require costly cascades of membranes.
View Article and Find Full Text PDFJ Dtsch Dermatol Ges
January 2025
Department of Dermatology, University Hospital Tuebingen, Tuebingen, Germany.
Background: Up to now, the optimal duration of immune checkpoint inhibitors (ICI) has not been evaluated in prospective studies. However, current clinical practice requires decisions to be made regarding the duration of ICI in complete responders.
Material And Methods: A survey was sent to 80 DeCOG skin cancer centers to assess how decisions are made on treatment duration of ICI in melanoma after having reached complete response, and staging intervals after ICI discontinuation.
BAY 2413555 is a novel selective and reversible positive allosteric modulator of the type 2 muscarinic acetylcholine (M2) receptor, aimed at enhancing parasympathetic signaling and restoring cardiac autonomic balance for the treatment of heart failure (HF). This study tested the safety, tolerability and pharmacokinetics of this novel therapeutic option. REMOTE-HF was a multicenter, double-blind, randomized, placebo-controlled, phase Ib dose-titration study with two active arms.
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