Signal strength-based positioning in wireless sensor networks is a key technology for seamless, ubiquitous localization, especially in areas where Global Navigation Satellite System (GNSS) signals propagate poorly. To enable wireless local area network (WLAN) location fingerprinting in larger areas while maintaining accuracy, methods to reduce the effort of radio map creation must be consolidated and automatized. Gaussian process regression has been applied to overcome this issue, also with auspicious results, but the fit of the model was never thoroughly assessed. Instead, most studies trained a readily available model, relying on the zero mean and squared exponential covariance function, without further scrutinization. This paper studies the Gaussian process regression model selection for WLAN fingerprinting in indoor and outdoor environments. We train several models for indoor/outdoor- and combined areas; we evaluate them quantitatively and compare them by means of adequate model measures, hence assessing the fit of these models directly. To illuminate the quality of the model fit, the residuals of the proposed model are investigated, as well. Comparative experiments on the positioning performance verify and conclude the model selection. In this way, we show that the standard model is not the most appropriate, discuss alternatives and present our best candidate.
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http://dx.doi.org/10.3390/s150922587 | DOI Listing |
Int J Part Ther
March 2025
Institute of Medical Physics and Radiation Protection, University of Applied Sciences, Giessen, Germany.
Purpose: The spot size of scanned particle beams is of crucial importance for the correct dose delivery and, therefore, plays a significant role in the quality assurance (QA) of pencil beam scanning ion beam therapy.
Materials And Methods: This study compares 5 detector types-radiochromic film, ionization chamber (IC) array, flat panel detector, multiwire chamber, and IC-for measuring the spot size of proton and carbon ion beams.
Results: Variations of up to 30% were found between detectors, underscoring the impact of detector choice on QA outcomes.
J Appl Stat
June 2024
Department of Biostatistics, University of Florida, Gainesville, FL, USA.
Due to the tremendous heterogeneity of disease manifestations, many complex diseases that were once thought to be single diseases are now considered to have disease subtypes. Disease subtyping analysis, that is the identification of subgroups of patients with similar characteristics, is the first step to accomplish precision medicine. With the advancement of high-throughput technologies, omics data offers unprecedented opportunity to reveal disease subtypes.
View Article and Find Full Text PDFLangmuir
January 2025
Department of Chemistry and Biochemistry, Fordham University, 441 East Fordham Road, The Bronx, New York 10458, United States.
The first protocells are speculated to have arisen from the self-assembly of simple abiotic carboxylic acids, alcohols, and other amphiphiles into vesicles. To study the complex process of vesicle formation, we combined laboratory automation with AI-guided experimentation to accelerate the discovery of specific compositions and underlying principles governing vesicle formation. Using a low-cost commercial liquid handling robot, we automated experimental procedures, enabling high-throughput testing of various reaction conditions for mixtures of seven (7) amphiphiles.
View Article and Find Full Text PDFCell Rep Med
January 2025
Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, USA. Electronic address:
Alpha-1 antitrypsin (AAT) deficiency (AATD) is a monogenic disease caused by misfolding of AAT variants resulting in gain-of-toxic aggregation in the liver and loss of monomer activity in the lung leading to chronic obstructive pulmonary disease (COPD). Using high-throughput screening, we discovered a bioactive natural product, phenethyl isothiocyanate (PEITC), highly enriched in cruciferous vegetables, including watercress and broccoli, which improves the level of monomer secretion and neutrophil elastase (NE) inhibitory activity of AAT-Z through the endoplasmic reticulum (ER) redox sensor protein disulfide isomerase (PDI) A4 (PDIA4). The intracellular polymer burden of AAT-Z can be managed by combination treatment of PEITC and an autophagy activator.
View Article and Find Full Text PDFJ Hazard Mater
January 2025
State Key Laboratory of Water Environment Simulation, School of Environment, Beijing Normal University, Beijing 100875, P.R. China. Electronic address:
Antibiotics are emerging contaminants of significant concern, while previous research has mostly focused on their ecological or health impacts in isolation. This limited systematic research on its overall risk and the uncertainty relating to the risk evaluation is also unclear. This study addressed this gap by examining both ecological or health impacts by integrating interspecies correlation models, species sensitivity distribution curves, and health risk evaluation.
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