Fatty acids containing a C18 alkyl chain such as stearic acid (C18:0 fatty acid), oleic acid (C18:1 fatty acid) and linoleic acid (C18:2 fatty acid) are common emulsifiers in skin-care products and cosmetics and are also used in skin cleansers. In this study, we prepared calcium salts (Ca salts) of the above fatty acids to determine the effect of the degree of unsaturation of the alkyl chain. Scanning electron microscopy images and X-ray diffraction patterns show that C18:0 and C18:1 fatty acid Ca salts are plate-shaped, lamellar-crystalline powder, while C18:2 fatty acid Ca salt is amorphous powder. Therefore, C18:2 fatty acid Ca salt exhibits a lower lubrication ability than do C18:0 and C18:1 fatty acid Ca salts. In addition, the bactericidal ability against Staphylococcus aureus, Staphylococcus epidermidis and Propionibacterium acnes improved with increasing degree of unsaturation. These findings suggest that Ca salts of unsaturated fatty acids have potential applications in cleansing and cosmetic products.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.5650/jos.ess15090 | DOI Listing |
Sci Adv
January 2025
Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, China.
S-Palmitoylation is a reversible post-translational modification involving saturated fatty acid palmitate-to-cysteine linkage in the protein, which guides many aspects of macrophage physiology in health and disease. However, the precise role and underlying mechanisms of palmitoylation in infection of macrophages remain elusive. Here, we found that infection induced the expression of zinc-finger DHHC domain-type palmitoyl-transferases (ZDHHCs), particularly ZDHHC2, in mouse macrophages.
View Article and Find Full Text PDFOrg Lett
January 2025
Department of Chemistry, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama, Kanagawa 223-8522, Japan.
Human African trypanosomiasis (HAT) is one of the most lethal of the neglected tropical diseases. While the discovery of a novel antitrypanosomal drug is highly desired, the creation of a superior lead compound is challenging. Herein we report ukabamide (), which was isolated from a marine sp.
View Article and Find Full Text PDFRapid Commun Mass Spectrom
January 2025
Project Center of Advanced Mass Spectrometry Technologies, Skolkovo Institute of Science and Technology, Moscow, Russian Federation.
Rationale: Teaching mass spectrometry essentials is usually connected with one of the basic courses for undergrads. Thus, specific previous knowledge is required from students. However, the necessity of teaching mass spectrometry essentials to students of different academic specializations and multidisciplinary groups can arise in every academic group.
View Article and Find Full Text PDFFASEB J
January 2025
Department of Surgery, Center for Engineering in Medicine and Surgery, Massachusetts General Hospital, Boston, Massachusetts, USA.
Circulating monocytes contribute to the defense against pathogens and play a crucial role in maintaining immune homeostasis. While there is substantial evidence regarding the triggers of monocyte activation, our understanding of how monocyte function is restored toward homeostasis after activation remains limited. Here, we assessed the changes in monocyte anisocytosis upon activation in blood, measured by monocyte distribution width (MDW), a biomarker for sepsis.
View Article and Find Full Text PDFAdv Sci (Weinh)
January 2025
Liver Transplant Center, Transplant Center, West China Hospital, Sichuan University, Chengdu, 610041, China.
Recipients often suffer from hyperlactatemia during liver transplantation (LT), but whether hyperlactatemia exacerbates hepatic ischemia-reperfusion injury (IRI) after donor liver implantation remains unclear. Here, the role of hyperlactatemia in hepatic IRI is explored. In this work, hyperlactatemia is found to exacerbate ferroptosis during hepatic IRI.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!