AI Article Synopsis
- A study was conducted on pregnant Wistar rats to assess the effects of the antioxidant 2,2'-Methylenebis (4-ethyl-6-tert-buthylphenol) given at doses of 187, 375, and 750 mg/kg from days 7 to 17 of gestation.
- At higher doses (375 and 750 mg/kg), the rats showed signs of toxicity such as hair fluffing, diarrhea, suppressed body weight gain, and decreased food consumption, with two deaths reported in the highest dose group.
- While there were no significant fetal malformations observed, there was a slight increase in fetal deaths at the 750 mg/kg dose, indicating that the compound has weak lethal effects on fetal
Article Abstract
2,2'-Methylenebis (4-ethyl-6-tert-buthylphenol), an antioxidant, was given orally to pregnant Wistar rats by stomach intubation at the dose levels of 187, 375 or 750 mg/kg body weight during days 7 to 17 of gestation, and the effects of the compound on dams and fetal development were examined. In dams at the two higher doses of 375 and 750 mg/kg, toxic signs such as hair fluffing and diarrhoea were observed, and their body weight gain and food consumption were suppressed. Two dams which showed marked diarrhoea in the highest dose group of 750 mg/kg died. However, there was no evidence of fetal malformations attributable to the treatment of the compound in any of the dose group tested, though a slight increase in fetal death was found in the highest dose group. It is concluded that 2,2'-methylenebis (4-ethyl-6-tert-buthylphenol) has a weak lethal effect on fetal development but not a teratogenic effect in the rat.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!