AI Article Synopsis
- A liquid phase plasma process was used to create low molecular weight heparin, with the molecular weight decreasing as treatment time increased.
- The reaction did not change the essential characteristics of heparin nor produce any unwanted by-products.
- It is believed that active oxygen radicals generated during the plasma process caused the depolymerization of heparin.
Article Abstract
An liquid phase plasma process system was applied to the production of low molecular weight heparin. The molecular weight of produed heparin decreased with increasing liquid phase plasma treatment time. The abscission of the chemical bonds between the constituents of heparin by liquid phase plasma reaction did not alter the characteristics of heparin. Formation of any by-products due to side reaction was not observed. It is suggested that heparin was depolymerized by active oxygen radicals produced during the liquid phase plasma reaction.
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| http://dx.doi.org/10.1166/jnn.2015.10452 | DOI Listing |
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