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A case of neuron-derived neurotrophic factor-positive, syphilis-related membranous nephropathy that achieved spontaneous remission.
CEN Case Rep
December 2024
Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-Ku, Fukuoka, 812-8582, Japan.
Neuron-derived neurotrophic factor (NDNF) was discovered as a target antigen in membranous nephropathy (MN) caused by syphilis. However, there have been few reports of NDNF-positive MN in Japan. A 19-year-old female patient was admitted to our hospital with nephrotic syndrome and acute kidney injury.
View Article and Find Full Text PDFSafety assessment of disulfiram: real-world adverse event analysis based on FAERS database.
Front Psychiatry
November 2024
Department of Psychiatry, The School of Clinical Medicine, Hunan University of Chinese Medicine, Changsha, Hunan, China.
Article Synopsis
- * A total of 52,159,321 AE reports were reviewed, identifying 508 specifically linked to disulfiram, with major categories including off-label use, psychiatric symptoms, and liver issues, and signaling significant new potential AEs.
- * Despite its benefits as a repurposed medication in fields like oncology and infectious diseases, disulfiram carries risks such as hepatobiliary, psychiatric, and nervous system disorders that require careful monitoring by healthcare providers.
Atypical clinical debut associated with Jarisch Herxheimer reaction in an asplenic patient with leptospirosis: case report and review.
BMC Infect Dis
November 2024
Internal Medicine resident, Fundacion Universitaria Juan N Corpas, Fundación Clínica Shaio, Dg. 115a #70c - 75, Bogotá, Colombia.
Background: Leptospirosis poses a diagnostic challenge owing to its wide array of symptoms, ranging from asymptomatic cases and febrile syndromes to severe disease with a high mortality rate. Risk factors are associated with exposure and the immune response, particularly in immunosuppressed patients.
Case Presentation: A clinical case involving a 49-year-old patient with a history of splenectomy and no immunization schedule.
[Not Available].
Ugeskr Laeger
November 2024
Afdeling for Infektionssygdomme, Aarhus Universitetshospital.
Article Synopsis
- A 37-year-old woman was hospitalized with fever and muscle pain after returning from Mauritius.
- She developed severe respiratory and circulatory failure shortly after receiving intravenous ceftriaxone, with anaphylaxis and pulmonary embolism being ruled out.
- Ultimately, she tested positive for leptospirosis, and her critical condition was attributed to a Jarisch-Herxheimer reaction.
Isolated Intraocular Jarisch-Herxheimer Reaction Following Treatment for Syphilitic Chorioretinitis.
Cureus
August 2024
Department of Internal Medicine, Lilavati Hospital, Mumbai, IND.
A 39-year-old male patient presented with grossly reduced vision in the left eye for the past three months. Fundus evaluation revealed multiple discrete grayish-white deep chorioretinal lesions in the macular area. An optical coherence tomography (OCT) scan in the affected area was normal.
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